Potential Application of Electrical Stimulation in Stem Cell-Based Treatment against Hearing Loss.
Potential Application of Electrical Stimulation in Stem Cell-Based Treatment against Hearing Loss.
复制标题
电刺激在干细胞治疗听力损失中的潜在应用
DOI：
10.1155/2018/9506387
复制
发表时间：
2018
影响因子：
3.1
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Tang M;Yan X;Tang Q;Guo R;Da P;Li D
耳聋是一种常见的人类疾病，其主要原因是哺乳动物耳蜗毛细胞和螺旋神经节神经元（SGN）的不可逆损伤。目前，通过干细胞移植疗法替代受损或缺失的毛细胞和SGN是一种有效的治疗方法。然而，干细胞移植的存活率低，无法控制的分化阻碍了其应用。大多数研究人员都集中在生化因素来调节干细胞的生长和分化，而很少有研究使用物理因素进行。本文综述了目前干细胞治疗耳聋存在的问题，并介绍了电场刺激作为一种物理因素来调节干细胞的行为，促进干细胞治疗未来的听力损失。
Deafness is a common human disease, which is mainly caused by irreversible damage to hair cells and spiral ganglion neurons (SGNs) in the mammalian cochlea. At present, replacement of damaged or missing hair cells and SGNs by stem cell transplantation therapy is an effective treatment. However, the survival rate of stem cell transplantation is low, with uncontrollable differentiation hindering its application. Most researchers have focused on biochemical factors to regulate the growth and differentiation of stem cells, whereas little study has been performed using physical factors. This review intends to illustrate the current problems in stem cell-based treatment against deafness and to introduce electric field stimulation as a physical factor to regulate stem cell behavior and facilitate stem cell therapy to treat hearing loss in the future.
登录
查看更多内容
DOI：
10.1007/s101620020018
发表时间：
2002-06-01
影响因子：
2.4
作者：
Boyle, R;Highstein, SM;Xu, JP
通讯作者：
Xu, JP
影响因子：
2.5
作者：
Goode, CT;Carey, JP;Rubel, EW
通讯作者：
Rubel, EW
DOI：
10.1523/jneurosci.2845-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kujawa SG;Liberman MC
通讯作者：
Liberman MC
影响因子：
56.9
作者：
Clarke, DL;Johansson, CB;Frisén, J
通讯作者：
Frisén, J
影响因子：
2.9
作者：
LAJTHA, LG
通讯作者：
LAJTHA, LG