Effect of nebracetam on the disruption of spatial cognition in rats.
Effect of nebracetam on the disruption of spatial cognition in rats.
复制标题
奈布拉西坦对大鼠空间认知破坏的影响。
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
M. Fujiwara
中科院分区：
文献类型：
--
作者：
K. Iwasaki;Y. Matsumoto;M. Fujiwara
中枢胆碱能功能减退导致空间认知的中断，而拟胆碱能药物改善这种中断。东莨菪碱（0.5mg/kg，i. p.）也有报道说会破坏大鼠的径向迷宫行为。Nebracetam（WEB 1881 FU）是一种新的促智候选药物，能够以10 mg/kg的剂量p.o.纠正东莨菪碱诱导的空间认知破坏。此外，奈拉西坦增强了氧震颤素诱导的小鼠震颤。这些结果表明奈拉西坦具有胆碱能增强作用。东莨菪碱诱导的空间认知中断以前已经报道，不仅通过拟胆碱药，而且通过脑去甲肾上腺素能药物如L-苏型-DOPS和金刚烷胺来改善。奈拉西坦可逆转东莨菪碱引起的额叶皮质和海马去甲肾上腺素含量降低的变化。奈拉西坦还降低了δ 9-四氢大麻酚（6 mg/kg，i. p.）诱导空间认知的破坏，据报道这与肾上腺素能神经系统的去甲肾上腺素能功能有关。这些结果表明，奈拉西坦的认知增强作用不仅涉及胆碱能机制，而且涉及海马和海马去甲肾上腺素能机制。
Central cholinergic hypofunction causes the disruption of spatial cognition, while cholinomimetics improve this disruption in rats. Scopolamine (0.5 mg/kg, i.p.) has also been reported to disrupt radial maze performance in rats. Nebracetam (WEB 1881 FU), a new nootropic candidate, was able to correct this scopolamine-induced disruption of spatial cognition at the dose of 10 mg/kg, p.o. Furthermore, nebracetam enhanced oxotremorine-induced tremors in mice. These results indicate that nebracetam has a cholinergic enhancing effect. The scopolamine-induced disruption of spatial cognition has been previously reported to improve not only by cholinomimetics but also by brain noradrenergic drugs such as L-threo-DOPS and amantadine. Nebracetam reversed the change of brain noradrenaline contents in the frontal cortex and hippocampus in which the noradrenaline content decreased by treatment with scopolamine. Nebracetam also decreased the delta 9-tetrahydrocannabinol (6 mg/kg, i.p.)-induced disruption of spatial cognition, which was reported to be related to the lymbic noradrenergic function. These results suggest that the cognitive enhancing effect of nebracetam involves not only cholinergic mechanisms but also involves lymbic and hippocampal noradrenergic mechanisms.
影响因子：
56.9
作者：
COYLE, JT;PRICE, DL;DELONG, MR
通讯作者：
DELONG, MR
预测试β-内啡肽和氧化震颤素增强保留，东莨菪碱逆转保留。
DOI：
10.1016/s0163-1047(88)90922-3
发表时间：
1988
期刊：
Behavioral and neural biology
影响因子：
--
作者：
Brioni,JD;Izquierdo,I
通讯作者：
Izquierdo,I
与毒蕈碱受体亚型结合的激动剂的放射自显影分析。
影响因子：
5.8
作者：
MesserJr,WS;Ellerbrock,B;Price,M;Hoss,W
通讯作者：
Hoss,W