Prediction of prostate cancer from prostate biopsy in Chinese men using a genetic score derived from 24 prostate cancer risk-associated SNPs.
Prediction of prostate cancer from prostate biopsy in Chinese men using a genetic score derived from 24 prostate cancer risk-associated SNPs.
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DOI：
10.1002/pros.22661
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发表时间：
2013-11
期刊：
影响因子：
2.8
通讯作者：
Xu, Jianfeng
中科院分区：
文献类型：
--
作者：
Jiang, Haowen;Liu, Fang;Wang, Zhong;Na, Rong;Zhang, Limin;Wu, Yishuo;Zheng, Jie;Lin, Xiaoling;Jiang, Deke;Sun, Jielin;Zheng, S. Lilly;Ding, Qiang;Xu, Jianfeng
对中国男性前列腺癌（PCa）风险相关的24个单核苷酸多态性（snp）进行了编目。我们评估了这些snp是否可以独立预测前列腺活检的结果，并提高现有临床变量的预测性能。研究招募了2011年4月至2012年8月在中国上海华山医院连续行前列腺活检检测前列腺癌的308例患者。临床变量如血清前列腺特异性抗原（PSA）水平和外周血样本在10芯活检前收集。基于这24个PCa相关SNPs计算每个个体的遗传评分。308例患者行前列腺活检，141例（45.8%）诊断为前列腺癌。PCa患者的遗传评分（中位数= 1.30）显著高于无PCa患者（中位数= 0.89），P = 3.81 × 10−6。在调整年龄和总PSA后，差异仍然显著，P = 0.007。PCa检出率随遗传评分的增加而增加；遗传评分低（<0.5）、平均（0.5 - 1.5）和高（> - 1.5）的男性分别为26.3%、43.2%和60.0%,P−trend = 0.0003。对于PSA水平中度升高（1.6 ~ 20 ng/ml）的患者，总体PCa检出率为31.2%，遗传评分较低（<0.5）、平均（0.5 ~ 1.5）和较高（>1.5）的男性，PCa检出率分别为16.7%、31.2%和40.9%,P−trend = 0.03。然而，对于PSA 2: 20 ng/ml的患者，无论遗传评分如何，PCa的检出率都很高（>69%）。基于前列腺癌风险相关snp的遗传评分是中国男性前列腺活检结果的独立预测因子，可能有助于确定前列腺癌风险“灰色地带”患者是否需要前列腺活检。
Twenty-four prostate cancer (PCa) risk-associated single nucleotide polymorphisms (SNPs) in Chinese men have been cataloged. We evaluated whether these SNPs can independently predict outcomes of prostate biopsy, and improve the predictive performance of existing clinical variables. Three hundred eight consecutive patients that underwent prostate biopsy for detection of PCa at Huashan Hospital, Shanghai, China between April 2011 and August 2012 were recruited. Clinical variables such as serum prostate-specific antigen (PSA) levels and peripheral blood samples were collected prior to a 10-core biopsy. A genetic score based on these 24 PCa associated SNPs was calculated for each individual. Among 308 patients underwent prostate biopsy, 141 (45.8%) were diagnosed with PCa. Genetic score was significantly higher in patients with PCa (median = 1.30) than without (median = 0.89), P = 3.81 × 10−6. The difference remained significant after adjusting for age and total PSA, P = 0.007. The PCa detection rate increased with increasing genetic score; 26.3%, 43.2%, and 60.0% for men with lower (<0.5), average (0.5–1.5), and higher (>1.5) genetic score, respectively, P−trend = 0.0003. For patients with moderately elevated PSA levels (1.6–20 ng/ml), the PCa detection rate was 31.2% overall and was 16.7%, 31.2%, and 40.9% for men with lower (<0.5), average (0.5–1.5), and higher (>1.5) genetic score, respectively, P−trend = 0.03. For patients with PSA 2: 20 ng/ml, however, the PCa detection rates were high (>69%) regardless of genetic score. A genetic score based on PCa risk-associated SNPs is an independent predictor of prostate biopsy outcomes in Chinese men and may be helpful to determine the need for prostate biopsy among patients within a ‘‘gray zone’’ of PCa risk.
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