Systematic confirmation study of reported prostate cancer risk-associated single nucleotide polymorphisms in Chinese men.
Systematic confirmation study of reported prostate cancer risk-associated single nucleotide polymorphisms in Chinese men.
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DOI：
10.1111/j.1349-7006.2011.02036.x
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发表时间：
2011-10
期刊：
影响因子：
5.7
通讯作者：
Xu J
中科院分区：
文献类型：
--
作者：
Liu F;Hsing AW;Wang X;Shao Q;Qi J;Ye Y;Wang Z;Chen H;Gao X;Wang G;Chu LW;Ding Q;OuYang J;Gao X;Huang Y;Chen Y;Gao YT;Zhang ZF;Rao J;Shi R;Wu Q;Wang M;Zhang Z;Zhang Y;Jiang H;Zheng J;Hu Y;Guo L;Lin X;Tao S;Jin G;Sun J;Lu D;Zheng SL;Sun Y;Mo Z;Xu J
More than 30 prostate cancer (PCa) risk-associated loci have been identified in populations of European descent by genome-wide association studies (GWAS). We hypothesized that a subset of these loci may be associated with PCa risk in Chinese men. To test this hypothesis, 33 single nucleotide polymorphisms (SNPs), one each from the 33 independent PCa risk-associated loci reported in populations of European descent, were investigated for their associations with PCa risk in a case-control study of Chinese men (1,108 cases and 1,525 controls). We found that 11 of the 33 SNPs were significantly associated with PCa risk in Chinese men (P < 0.05). The reported risk alleles were associated with increased risk for PCa, with allelic odds ratios ranging from 1.12 to 1.44. The most significant locus was located on 8q24 Region 2 (rs16901979, P = 5.14×10−9) with a genome-wide significance (P < 10−8), and three loci reached the Bonferroni correction significance level (P < 1.52×10−3), including 8q24 Region 1 (rs1447295, P = 7.04×10−6), 8q24 Region 5 (rs10086908, P = 9.24×10−4), and 8p21 (rs1512268, P = 9.39×10−4). Our results suggest that a subset of the PCa risk-associated SNPs discovered by GWAS among men of European descent is also associated with PCa risk in Chinese men. This finding provides evidence of ethnic differences and similarity in genetic susceptibility to PCa. GWAS in Chinese men are needed to identify Chinese-specific PCa risk-associated SNPs.
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