Immunomodulatory Effects of Lepidium meyenii Walp. Polysaccharides on an Immunosuppression Model Induced by Cyclophosphamide.
Immunomodulatory Effects of Lepidium meyenii Walp. Polysaccharides on an Immunosuppression Model Induced by Cyclophosphamide.
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Lepidium meyenii Walp 的免疫调节作用。
DOI：
10.1155/2022/1210890
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发表时间：
2022
影响因子：
4.1
通讯作者：
Wang, Lin-yuan
中科院分区：
文献类型：
--
作者：
Fei, Wen-ting;Yue, Na;Li, Ai-min;Yu, Shu-hui;Zhao, Dan-ping;Zhu, Ying-li;Wang, Chun;Zhang, Jian-jun;Wang, Lin-yuan
Lepidium meyenii Walp. (Maca) has emerged as a functional plant food and traditional herb owing to its biological activities; Maca polysaccharides as an important active component of Maca have good immunomodulatory effect; however, studies on the immunomodulatory effect of Maca polysaccharides are mainly focused on macrophages; little attention has been devoted to the mechanisms and other immune cells. This study is aimed at investigating the immunomodulatory effects and mechanisms of Maca polysaccharides. Sixty mice were divided into five groups, and the mice were injected with cyclophosphamide to establish an immunosuppression model except for those in the common group. The body weights were measured, as well as immune-related indices, such as organ indices, haematological parameters, lymphocyte cycle, and proliferation, cytokine, and protein expression levels. The weight loss and immune organ index decline caused by cyclophosphamide could be reversed by MP. Furthermore, MP increased WBC and HGB counts and reduced the ratio of G0/G1 phase obviously, increased the proportion of S phase and G2/M phase in peripheral blood lymphocytes, increased the counts of CD4+ T cells and the ratio of CD4+/CD8+, and reduced the inhibition rate of splenic lymphocytes. MP affected the production of cytokines by increasing IFN-γ, TNF-α, and IL-2 levels and by decreasing IL-4 levels. MP increased the mRNA expression of T-bet and the protein expression of Bcl-2 in the spleen and decreased the protein expression of caspase-3 and Bax. Maca polysaccharides might be the basic material for Maca's immunomodulatory effect. The mechanism was perhaps related to inhibiting lymphocyte apoptosis and promoting the balance of Th1/Th2 cell subsets.
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影响因子：
2.2
作者：
Chakir, H;Wang, HP;Scott, FW
通讯作者：
Scott, FW
影响因子：
5.5
作者：
Correa, Ismael;Veny, Marisol;Salas, Azucena
通讯作者：
Salas, Azucena
影响因子：
5.6
作者：
Liu, Xiao;Zhang, Zhaojian;Wang, Xiaoying
通讯作者：
Wang, Xiaoying
影响因子：
16.6
作者：
Haabeth, Ole Audun Werner;Lorvik, Kristina Berg;Hammarstrom, Clara;Donaldson, Ian M.;Haraldsen, Guttorm;Bogen, Bjarne;Corthay, Alexandre
通讯作者：
Corthay, Alexandre
影响因子：
11.2
作者：
Huang, Yee;Jiang, Chunmao;Wang, Deyun
通讯作者：
Wang, Deyun