Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory (11) C-UCB-J positron emission tomography study in humans.
Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory (11) C-UCB-J positron emission tomography study in humans.
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DOI：
10.1111/adb.13123
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发表时间：
2022-03
影响因子：
3.4
通讯作者：
Malison RT
中科院分区：
文献类型：
--
作者：
Angarita GA;Worhunsky PD;Naganawa M;Toyonaga T;Nabulsi NB;Li CR;Esterlis I;Skosnik PD;Radhakrishnan R;Pittman B;Gueorguieva R;Potenza MN;Finnema SJ;Huang Y;Carson RE;Malison RT
Preclinical studies have revealed robust and long-lasting alterations in dendritic spines in the brain following cocaine exposure. Such alterations are hypothesized to underlie enduring maladaptive behaviors observed in cocaine use disorder (CUD). The current study explored whether synaptic density is altered in CUD. Fifteen individuals with DSM-5 CUD and 15 demographically matched healthy control (HC) subjects participated in a single 11C-UCB-J positron emission tomography scan to assess density of synaptic vesicle protein 2A (SV2A). The volume of distribution (VT) and the plasma free fraction-corrected form of the total volume of distribution (VT/fP) were analyzed in the anterior cingulate (ACC), dorsomedial and ventromedial prefrontal cortex (PFC), lateral and medial orbitofrontal cortex (OFC), and ventral striatum. A significant diagnostic-group-by-region interaction was observed for VT and VT/fP. Post-hoc analyses revealed no differences on VT while for VT/fP showed lower values in CUD as compared to HC subjects in the ACC (−10.9%, p=0.02), ventromedial PFC (−9.9%, p=0.02), and medial OFC (−9.9%, p=0.04). Regional VT/fP values in CUD, though unrelated to measures of lifetime cocaine use, were positively correlated with the frequency of recent cocaine use (p=0.02–0.03) and negatively correlated with cocaine abstinence (p=0.008–0.03). These findings provide initial preliminary in vivo evidence of altered (lower) synaptic density in the PFC of humans with CUD. Cross-sectional variation in SV2A availability as a function of recent cocaine use and abstinence suggests that synaptic density may be dynamically and plastically regulated by acute cocaine, an observation that merits direct testing by studies using more definitive longitudinal designs. This article studied whether synaptic density is altered in cocaine use disorder with 11C-UCB-J positron emission tomography It showed altered (lower) synaptic density in the medial prefrontal cortex of participants with cocaine use disorder in comparison to healthy controls Alterations in synaptic density among participants with cocaine use disorder showed correlations with frequency of recent cocaine use as well as hospital attained number of days abstinent.
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影响因子：
3.7
作者：
Connolly CG;Bell RP;Foxe JJ;Garavan H
通讯作者：
Garavan H
影响因子：
11
作者：
D'Souza, Deepak Cyril;Radhakrishnan, Rajiv;Skosnik, Patrick
通讯作者：
Skosnik, Patrick
影响因子：
17.1
作者：
Finnema, Sjoerd J.;Nabulsi, Nabeel B.;Carson, Richard E.
通讯作者：
Carson, Richard E.
影响因子：
3.5
作者：
de Jong, Hugo W. A. M.;van Velden, Floris H. P.;Lammertsma, Adriaan A.
通讯作者：
Lammertsma, Adriaan A.
影响因子：
16.2
作者：
Euston DR;Gruber AJ;McNaughton BL
通讯作者：
McNaughton BL