Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes.
Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes.
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DOI：
10.1016/j.mad.2021.111597
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发表时间：
2022-01
影响因子：
5.3
通讯作者：
Yuan R
中科院分区：
文献类型：
--
作者：
Zhu Y;Fang Y;Medina D;Bartke A;Yuan R
越来越多的证据表明，对发育特征的影响可能会对晚年的衰老和健康产生长期影响。二甲双胍是一种广泛用于治疗2型糖尿病的药物，也用于延迟性早熟女孩的性成熟。本报告重点研究二甲双胍对发育和代谢特征的影响。异种小鼠（UM-HET3）采用腹膜内注射治疗。 15 至 56 天之间服用二甲双胍。我们的研究结果表明，两性的体重和食物消耗量均有所增加，而雌性的性成熟则延迟。两性的尾长和循环胰岛素样生长因子 1 (IGF1) 水平均显着增加。胰岛素耐量测试没有发现显着差异，但男性的葡萄糖耐量显着降低。二甲双胍治疗以性别特异性方式改变了循环脂联素和胰岛素水平。定量胰岛素敏感性检查指数（QUICKI）分析表明，二甲双胍治疗增加了雌性幼犬的胰岛素敏感性，但对雄性幼犬具有相反的效果。这项研究表明，生命早期的二甲双胍治疗会以性别特异性和非特异性方式改变小鼠的发育和代谢。二甲双胍的这些作用可能对衰老相关特征产生长期影响。
Accumulating evidence suggests that the influence on developmental traits might have long-term effects on aging and health later in life. Metformin is a widely used drug for treating type 2 diabetes and is also used for delaying sexual maturation in girls with precocious puberty. The current report focuses on investigating the effects of metformin on development and metabolic traits. Heterogeneous mice (UM-HET3) were treated with i.p. metformin between the ages of 15 and 56 days. Our results show that body weight and food consumption were increased in both sexes, and sexual maturation was delayed in females. Tail length and circulating insulin-like growth factor 1 (IGF1) levels were significantly increased in both sexes. No significant difference was found in insulin tolerance test, but glucose tolerance was significantly reduced in the males. Circulating adiponectin and insulin levels were altered by metformin treatment in a sex-specific manner. Analysis of quantitative insulin sensitivity check index (QUICKI) suggests that metformin treatment increased insulin sensitivity in female pups, but had opposite effect in male pups. This study revealed that early life metformin treatment alters development and metabolism of mice in both sex-specific and non-specific manners. These effects of metformin may have long-term impacts on aging-related traits.
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影响因子：
6.2
作者：
Anisimov, Vladimir N.;Bartke, Andrzej
通讯作者：
Bartke, Andrzej
IGF1R +/-小鼠中IGF-1R信号的降低会改变衰老吗？
影响因子：
3.7
作者：
Bokov AF;Garg N;Ikeno Y;Thakur S;Musi N;DeFronzo RA;Zhang N;Erickson RC;Gelfond J;Hubbard GB;Adamo ML;Richardson A
通讯作者：
Richardson A
影响因子：
6.7
作者：
Ibanez, Lourdes;Lopez-Bermejo, Abel;de Zegher, Francis
通讯作者：
de Zegher, Francis
影响因子：
4.1
作者：
Faggi, Lara;Giustina, Andrea;Tulipano, Giovanni
通讯作者：
Tulipano, Giovanni
影响因子：
5.2
作者：
Bartke, Andrzej;Evans, Tracy R.;Musters, C. J. M.
通讯作者：
Musters, C. J. M.