The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson's disease.
The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson's disease.
复制标题
DOI：
10.1007/s00415-020-10156-3
复制
发表时间：
2021-03
影响因子：
6
通讯作者：
PRIAMO study group
中科院分区：
文献类型：
--
作者：
Picillo M;Palladino R;Erro R;Alfano R;Colosimo C;Marconi R;Antonini A;Barone P;PRIAMO study group
探讨性别、年龄对帕金森病早期前驱期便秘与疾病表型关系的影响。来自PRIAMO研究的总共385名帕金森病患者根据前驱便秘的存在进行分类，并随访24个月。应用多变量混合效应模型。所有分析均按性别（64.1%男性）和中位年龄（性别不同：男性67岁，女性68岁）单独进行。至于性别，前驱期便秘仅与女性的注意力/记忆力投诉和冷漠症状相关。至于年龄，前驱期便秘仅在老年患者中与较低的认知和较高的冷漠评分相关。前驱期便秘预计女性和老年患者从最早阶段起就会出现认知能力下降和更严重的冷漠。帕金森病前驱标志物的性别和年龄相关异质性可能影响疾病表型本文的在线版本（10.1007/s 00415 -020-10156-3）包含补充材料，可供授权用户使用。
To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson’s disease at early stages. A total of 385 Parkinson’s disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women). As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only. Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson’s disease may impact disease phenotype. The online version of this article (10.1007/s00415-020-10156-3) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
8.6
作者：
Barone, Paolo;Antonini, Angelo;Del Dotto, Paolo
通讯作者：
Del Dotto, Paolo
影响因子：
2.4
作者：
Verkuijl, Sanne J.;Meinds, Rob J.;Broens, Paul M. A.
通讯作者：
Broens, Paul M. A.
影响因子：
6
作者：
Martinez-Martin, Pablo;Pecurariu, Cristian Falup;Chaudhuri, Kallol Ray
通讯作者：
Chaudhuri, Kallol Ray
影响因子：
5.1
作者：
Picillo, M.;Palladino, R.;Antonini, A.
通讯作者：
Antonini, A.
影响因子：
4.1
作者：
Jones, Jacob D.;Rahmani, Elizabeth;Jacobs, Jonathan P.
通讯作者：
Jacobs, Jonathan P.