Epilepsy Lesion Localization is not Predicted by Developmental Venous Anomaly Location or its FDG-PET Metabolic Activity.
Epilepsy Lesion Localization is not Predicted by Developmental Venous Anomaly Location or its FDG-PET Metabolic Activity.
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DOI：
10.1111/jon.12722
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发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Nabavizadeh SA
中科院分区：
文献类型：
--
作者：
Lazor JW;Stein JM;Schmitt JE;Davis KA;Nabavizadeh SA
本研究的目的是将癫痫患者发育性静脉异常 (DVA) 的位置和代谢活动与发作期/发作间期脑电图 (EEG) 确定的癫痫病灶联系起来。对接受脑 18F-氟脱氧葡萄糖正电子发射断层扫描 (18F-FDG-PET) 和磁共振成像 (MRI) 的 DVA 癫痫患者进行回顾性研究。分析 MRI 检查以确定 DVA 位置和相关结构发现的特征。 MRI 和 PET 图像被共同配准，并对 DVA 区域的 18F-FDG 摄取进行评估。审查每个受试者的电子病历，通过发作/发作间期脑电图确定癫痫症状学和癫痫病灶部位。包括 25 名患者的 28 名 DVA。 12 例 DVA 在 18F-FDG-PET 上显示局部代谢异常。脑电图 DVA 部位与癫痫发作焦点之间没有显着相关性。三名受试者的 DVA 位置与 EEG 癫痫焦点一致，并且所有三名受试者在 18F-FDG-PET 上均表现出代谢低下。这种意义仍然不确定，因为其中一名 DVA 与海绵体瘤相关，海绵瘤可能是真正的癫痫病灶，并且其中一名患者接受了 DVA 切除术，但癫痫发作频率并未降低。此外，DVA 代谢活动与 DVA-EEG 脑叶或侧向一致性之间不存在统计学显着关系。在该样本中，DVA 的位置和癫痫病灶之间没有显着相关性，并且 DVA 区域内的代谢减退不能预测 EEG/DVA 共定位。随着 18F-FDG-PET 在癫痫评估中的应用不断增加，了解这种较差的相关性对于避免癫痫患者的诊断混乱和潜在不必要的手术非常重要。
This study’s purpose is to correlate location and metabolic activity of developmental venous anomalies (DVAs) in epilepsy patients to the seizure focus as determined by ictal/interictal encephaloelectrogram (EEG). A retrospective search was performed for epilepsy patients with DVAs who underwent brain 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) and magnetic resonance imaging (MRI). MRI exams were analyzed to characterize DVA location and associated structural findings. MRI and PET images were co-registered and assessment of 18F-FDG uptake in the DVA territory was performed. The electronic medical record was reviewed for each subject to determine seizure semiology and site of seizure focus by ictal/interictal EEG. Twenty-eight DVAs in 25 patients were included. Twelve DVAs demonstrated regional metabolic abnormality on 18F-FDG-PET. There was no significant correlation between DVA site and seizure focus on EEG. DVA location was concordant with EEG seizure focus in three subjects, and all three demonstrated hypometabolism on 18F-FDG-PET. This significance remains indeterminate, as one of these DVAs was associated with cavernoma, which could serve as the true seizure focus, and one of the patients underwent resection of the DVA without decrease in seizure frequency. Furthermore, there was no statistically significant relationship between DVA metabolic activity and DVA-EEG lobar or laterality concordance. In this sample, there is no significant correlation between location of DVA and seizure focus, and hypometabolism within the DVA territory is not predictive of EEG/DVA co-localization. As use of 18F-FDG-PET for evaluation of epilepsy increases, knowledge of this poor correlation is important to avoid diagnostic confusion and potentially unnecessary surgery in epilepsy patients.
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影响因子：
4.2
作者：
Frischer, Josa M.;Goed, Sabine;Gruber, Andreas;Saringer, Walter;Grabner, Guenther;Gatterbauer, Brigitte;Kitz, Klaus;Holzer, Sabrina;Kronnerwetter, Claudia;Hainfellner, Johannes A.;Knosp, Engelbert;Trattnig, Siegfried
通讯作者：
Trattnig, Siegfried
影响因子：
4.1
作者：
Mullan, S;Mojtahedi, S;Macdonald, RL
通讯作者：
Macdonald, RL
影响因子：
4.8
作者：
Lazor, Jillian W.;Schmitt, J. Eric;Nabavizadeh, S. Ali
通讯作者：
Nabavizadeh, S. Ali
影响因子：
6
作者：
Dussaule, Claire;Masnou, Pascal;Denier, Christian
通讯作者：
Denier, Christian
DOI：
10.3174/ajnr.a4116
发表时间：
2015-03
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
De Ciantis A;Barkovich AJ;Cosottini M;Barba C;Montanaro D;Costagli M;Tosetti M;Biagi L;Dobyns WB;Guerrini R
通讯作者：
Guerrini R