Modelling and measurement of laser-generated focused ultrasound: Can interventional transducers achieve therapeutic effects?
Modelling and measurement of laser-generated focused ultrasound: Can interventional transducers achieve therapeutic effects?
复制标题
激光产生的聚焦超声的建模和测量：介入透明剂可以实现治疗效果吗？
DOI：
10.1121/10.0004302
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Alles EJ
中科院分区：
文献类型：
--
作者：
Aytac-Kipergil E;Desjardins AE;Treeby BE;Noimark S;Parkin IP;Alles EJ
用于超声治疗的激光生成聚焦超声（LGFU）换能器通常具有大直径（6-15 mm），但介入应用需要较小的横向尺寸（<4 mm）。为了解决微型LGFU换能器是否可以在焦点处产生足够的压力以实现治疗效果的问题，进行了建模和测量研究。测量进行了线性和非线性传播的各种照明方案，并与模型进行比较。该模式包括几项创新。首先，该模型允许LGFU换能器的表面上的径向变化的声输入分布，其产生于撞击在弯曲的换能器表面上的激发光。这种对源的现实表示可以防止高估可实现的压力（此处显示高达1.8倍）。其次，提出了一种替代的逆高斯照明范例，以实现更高的压力;在测量中观察到35%的增加。模拟表明，小至3.5 mm的LGFU换能器可以在焦点处产生足够的峰值负压，以超过水和血液中的空化阈值。这种规模的换能器可以与介入设备集成，从而为体内治疗应用开辟新的机会。
Laser-generated focused ultrasound (LGFU) transducers used for ultrasound therapy commonly have large diameters (6–15 mm), but smaller lateral dimensions (<4 mm) are required for interventional applications. To address the question of whether miniaturized LGFU transducers could generate sufficient pressure at the focus to enable therapeutic effects, a modelling and measurement study is performed. Measurements are carried out for both linear and nonlinear propagation for various illumination schemes and compared with the model. The model comprises several innovations. First, the model allows for radially varying acoustic input distributions on the surface of the LGFU transducer, which arise from the excitation light impinging on the curved transducer surfaces. This realistic representation of the source prevents the overestimation of the achievable pressures (shown here to be as high as 1.8 times). Second, an alternative inverse Gaussian illumination paradigm is proposed to achieve higher pressures; a 35% increase is observed in the measurements. Simulations show that LGFU transducers as small as 3.5 mm could generate sufficient peak negative pressures at the focus to exceed the cavitation threshold in water and blood. Transducers of this scale could be integrated with interventional devices, thereby opening new opportunities for therapeutic applications from inside the body.
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影响因子：
4
作者：
Lee, Taehwa;Ok, Jong G.;Baac, Hyoung Won
通讯作者：
Baac, Hyoung Won
影响因子：
2.9
作者：
Miller, DL;Thomas, RM
通讯作者：
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影响因子：
3.6
作者：
Aytac-Kipergil, E.;Alles, E. J.;Desjardins, A. E.
通讯作者：
Desjardins, A. E.
采用蜡烛烟灰纳米颗粒-聚二甲基硅氧烷复合材料涂覆光声透镜的微型光纤高强度聚焦超声装置
影响因子：
3.8
作者：
Li, Yao;Guo, Zhendong;Chen, Sung-Liang
通讯作者：
Chen, Sung-Liang
DOI：
10.1016/j.jconrel.2015.08.033
发表时间：
2015-12-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Di J;Kim J;Hu Q;Jiang X;Gu Z
通讯作者：
Gu Z