Neonatal agonism of ERalpha masculinizes serotonergic (5-HT) projections to the female rat ventromedial nucleus of the hypothalamus (VMN) but does not impair lordosis.
Neonatal agonism of ERalpha masculinizes serotonergic (5-HT) projections to the female rat ventromedial nucleus of the hypothalamus (VMN) but does not impair lordosis.
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DOI：
10.1016/j.bbr.2008.09.026
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发表时间：
2009-01-23
影响因子：
2.7
通讯作者：
Mickens, Jillian A.
中科院分区：
文献类型：
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作者：
Patisaul, Heather B.;Adewale, Heather B.;Mickens, Jillian A.
已知5-羟色胺（5-HT）在抑制男性脊柱前凸反应中发挥作用。我们以前已经表明，有一个性别差异的5-羟色胺免疫反应（5-HT-IR）纤维在腹外侧部的成人下丘脑腹内侧核（VMNvl）和新生儿管理的雌二醇（E2）增加5-HT-IR在女性VMNvl男性典型的水平。在这里，我们证明，出生后给予ERα激动剂1，3，5-三（4-羟基苯基）-4-丙基-1H-吡唑（PPT），而不是ERβ激动剂二芳基丙腈（DPN），也使雌性VMNvl中的5-HT-ir雄性化，表明ERα在此过程中的机制作用。通过脊柱前凸商数确定的性感受性不受PPT或DPN治疗的影响，但几乎被苯甲酸雌二醇（EB）消除，雌二醇是一种对ERα和ERβ具有高亲和力的合成雌激素。总的来说，这些观察结果表明，出生后雌激素通过ERα依赖性机制增加5-HT投射到VMNvl的密度，但这种增加的抑制性输入不足以抑制脊柱前凸反应。
Serotonin (5-HT) is known to play a role in the suppression of the lordosis response in males. We have previously shown that there is a sex difference in the density of 5-HT immunoreactive (5-HT-ir) fibers in the ventrolateral division of the adult ventromedial nucleus of the hypothalamus (VMNvl) and that neonatal administration of estradiol (E2) increases 5-HT-ir in the female VMNvl to male-typical levels. Here we demonstrate that postnatal administration of the ERα agonist 1,3,5-tris(4-Hydroxyphenyl)-4-propyl-1H-pyrazole (PPT), but not the ERβ agonist diarylpropionitrile (DPN), also masculinizes 5-HT-ir in the female VMNvl, suggesting a mechanistic role for ERα in this process. Sexual receptivity, as ascertained by the lordosis quotient, was unaffected by either PPT or DPN treatment but nearly abolished by estradiol benzoate (EB), a synthetic estrogen with high affinity for both ERα and ERβ. Collectively, these observations show that postnatal estrogens increase the density of 5-HT projections to the VMNvl via an ERα dependent mechanism, but that this increased inhibitory input is not sufficient to suppress the lordosis response.
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影响因子：
3.2
作者：
Jacob, DA;Temple, JL;Rissman, EF
通讯作者：
Rissman, EF
影响因子：
4.8
作者：
Kuiper, GGJM;Lemmen, JG;Gustafsson, JÄ
通讯作者：
Gustafsson, JÄ
影响因子：
3.5
作者：
KONDO, Y;SHINODA, A;ARAI, Y
通讯作者：
ARAI, Y
影响因子：
2.9
作者：
MATHEWS, D;GREENE, SB;HOLLINGSWORTH, EM
通讯作者：
HOLLINGSWORTH, EM
影响因子：
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作者：
Frye, CA
通讯作者：
Frye, CA