The universe of galectin-binding partners and their functions in health and disease.
The universe of galectin-binding partners and their functions in health and disease.
复制标题
DOI：
10.1016/j.jbc.2023.105400
复制
发表时间：
2023-12
影响因子：
4.8
通讯作者：
Rabinovich, Gabriel A.
中科院分区：
文献类型：
--
作者：
Troncoso, Maria F.;Elola, Maria T.;Blidner, Ada G.;Sarrias, Luciana;Espelt, Maria, V;Rabinovich, Gabriel A.
半乳糖凝集素是一个进化上保守的聚糖结合蛋白家族，在多种生物学过程中发挥关键作用，包括组织修复、脂肪生成、免疫细胞稳态、血管生成和病原体识别。半乳糖凝集素及其配体的失调已在广泛的病理状况中观察到，包括癌症、自身免疫性炎症、感染、纤维化和代谢紊乱。通过蛋白质-聚糖或蛋白质-蛋白质相互作用，这些内源性凝集素可以形成这些过程的起始、延续和消退，表明它们在疾病监测和治疗中的潜在作用。然而，尽管取得了相当大的进展，但由于半乳糖凝集素的多样性、细胞靶点的多重性和受体混杂性，尚未完全了解半乳糖凝集素的生物学和治疗潜力。在这篇文章中，我们讨论了多个半乳糖凝集素结合的合作伙伴存在于不同的细胞类型，专注于他们的贡献，选定的生理和病理设置。了解半乳糖凝集素-配体相互作用的分子基础，特别是它们的聚糖依赖性，所选受体的生化性质和潜在的信号传导事件，可能有助于设计合理的治疗策略来控制广泛的病理条件。
Galectins, a family of evolutionarily conserved glycan-binding proteins, play key roles in diverse biological processes including tissue repair, adipogenesis, immune cell homeostasis, angiogenesis, and pathogen recognition. Dysregulation of galectins and their ligands has been observed in a wide range of pathologic conditions including cancer, autoimmune inflammation, infection, fibrosis, and metabolic disorders. Through protein–glycan or protein–protein interactions, these endogenous lectins can shape the initiation, perpetuation, and resolution of these processes, suggesting their potential roles in disease monitoring and treatment. However, despite considerable progress, a full understanding of the biology and therapeutic potential of galectins has not been reached due to their diversity, multiplicity of cell targets, and receptor promiscuity. In this article, we discuss the multiple galectin-binding partners present in different cell types, focusing on their contributions to selected physiologic and pathologic settings. Understanding the molecular bases of galectin–ligand interactions, particularly their glycan-dependency, the biochemical nature of selected receptors, and underlying signaling events, might contribute to designing rational therapeutic strategies to control a broad range of pathologic conditions.
登录
查看更多内容
成人神经系统的塑性和疾病中的信号素。
影响因子：
3.7
作者：
Carulli D;de Winter F;Verhaagen J
通讯作者：
Verhaagen J
影响因子：
2.7
作者：
Bojic-Trbojevic, Zanka;Krivokuca, Milica Jovanovic;Vicovac, Ljiljana
通讯作者：
Vicovac, Ljiljana
影响因子：
29
作者：
Bieniasz-Krzywiec, Pawel;Martin-Perez, Rosa;Mazzone, Massimiliano
通讯作者：
Mazzone, Massimiliano
影响因子：
6.4
作者：
Cao, Yi;Merling, Anette;Schwartz-Albiez, Reinhard
通讯作者：
Schwartz-Albiez, Reinhard
DOI：
10.1073/pnas.0903497106
发表时间：
2009-08-25
影响因子：
11.1
作者：
Chen, Huan-Yuan;Fermin, Agnes;Liu, Fu-Tong
通讯作者：
Liu, Fu-Tong