Adaptive Immunity Dysregulation in Acute Coronary Syndromes: From Cellular and Molecular Basis to Clinical Implications.

Adaptive Immunity Dysregulation in Acute Coronary Syndromes: From Cellular and Molecular Basis to Clinical Implications.
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DOI:
10.1016/j.jacc.2016.08.036
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发表时间:
2016-11-08
影响因子:
24
通讯作者:
Crea F
Crea F
中科院分区:
医学1区
文献类型:
--
作者:
Flego D;Liuzzo G;Weyand CM;Crea F

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虽然在过去的十年中,急性冠脉综合征(ACS)的早期预后有了很大的改善,但心血管疾病仍然是全球发病率和死亡率的主要原因。这主要是由于急性冠脉综合征的复发最终导致心力衰竭和心源性猝死的大流行,因此需要重新评估导致冠状动脉不稳定的机制。在这篇综述中,我们将讨论获得性免疫如何在急性冠脉综合征的发病机制中起作用的最新进展,以及这些新的致病概念所产生的临床意义。
Although the early outcome of acute coronary syndrome (ACS) has considerably improved in the last decade, cardiovascular diseases still represent the main cause of morbidity and mortality worldwide. This is mainly due to the fact that recurrence of ACS eventually leads to the pandemics of heart failure and sudden cardiac death, thus calling for a reappraisal of the mechanisms responsible for coronary instability. In this review, we will discuss recent advances in our understanding of how adaptive immunity contributes to the pathogenesis of ACS, as well as the clinical implications that arise from these new pathogenic concepts.
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