Adaptive Immunity Dysregulation in Acute Coronary Syndromes: From Cellular and Molecular Basis to Clinical Implications.
Adaptive Immunity Dysregulation in Acute Coronary Syndromes: From Cellular and Molecular Basis to Clinical Implications.
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DOI:
10.1016/j.jacc.2016.08.036
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发表时间:
2016-11-08
影响因子:
24
通讯作者:
Crea F
中科院分区:
文献类型:
--
作者:
Flego D;Liuzzo G;Weyand CM;Crea F
Although the early outcome of acute coronary syndrome (ACS) has considerably improved in the last decade, cardiovascular diseases still represent the main cause of morbidity and mortality worldwide. This is mainly due to the fact that recurrence of ACS eventually leads to the pandemics of heart failure and sudden cardiac death, thus calling for a reappraisal of the mechanisms responsible for coronary instability. In this review, we will discuss recent advances in our understanding of how adaptive immunity contributes to the pathogenesis of ACS, as well as the clinical implications that arise from these new pathogenic concepts.
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通讯作者:
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