Development of intrapancreatic transplantable model of pancreatic duct adenocarcinoma in Syrian golden hamsters.
Development of intrapancreatic transplantable model of pancreatic duct adenocarcinoma in Syrian golden hamsters.
复制标题
叙利亚金仓鼠胰管腺癌胰内移植模型的建立。
作者：
H. Egami;T. Tomioka;M. Tempero;D. Kay;P. Pour
胰腺内和皮下（SC）接种培养的胰腺癌细胞，来自诱导的原发性胰腺癌在叙利亚仓鼠，导致肿瘤采取在所有受体仓鼠。胰腺内移植物生长迅速，具有侵袭性，有2例转移至淋巴结和肝脏。相比之下，SC肿瘤生长相对较慢，并形成一个大的包裹肿块，没有浸润和转移。在组织学上，两个部位的肿瘤均表现为分化良好的导管型腺癌，类似于诱导的原发癌。与原发性诱发胰腺癌相似，两种同种异体移植物的肿瘤细胞均表达血型相关抗原，包括A、B、H、Le（B）、Le（y）、Le（x）和肿瘤相关抗原TAG-72。肿瘤细胞不表达Le（a）、CA 19-9、17-1A或DU-PAN-2。这些抗原的表达保留在转移瘤中，并呈现与同种异体移植物相同的反应模式。因此，胰腺内移植提供了一个快速的模型，生产胰腺癌与人类胰腺癌的形态相似性。
Intrapancreatic and subcutaneous (SC) inoculation of cultured pancreatic cancer cells, derived from an induced primary pancreatic cancer in a Syrian hamster, resulted in tumor take in all recipient hamsters. The intrapancreatic allografts grew rapidly, were invasive, and metastasized into the lymph nodes and liver in 2 of 9 cases. In comparison, SC tumors grew relatively slower and formed a large encapsulated mass without invasion and metastases. Histologically, tumors of both sites showed fairly well-differentiated adenocarcinomas of ductal/ductular type resembling the induced primary cancer. Similar to the primary induced pancreatic cancers, tumor cells of both allografts expressed blood-group-related antigens, including A, B, H, Le(b), Le(y), Le(x), and tumor-associated antigen TAG-72. The tumor cells did not express Le(a), CA 19-9, 17-1A, or DU-PAN-2. The expression of these antigens was retained in the metastases and presented the same patterns of reactivity as the allografts. Thus intrapancreatic transplantation provides a rapid model for production of pancreatic cancer with morphologic similarities to human pancreatic cancer.
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影响因子：
11.2
作者：
A. Thor;N. Ohuchi;C. Szpak;W. Johnston;J. Schlom
通讯作者：
A. Thor;N. Ohuchi;C. Szpak;W. Johnston;J. Schlom
影响因子：
15.9
作者：
BAST, RC;FEENEY, M;KNAPP, RC
通讯作者：
KNAPP, RC
DOI：
10.1073/pnas.79.15.4761
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
HERLYN, D;KOPROWSKI, H
通讯作者：
KOPROWSKI, H
针对人类 Leb 血型抗原的单克隆抗体。
DOI：
--
发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Brockhaus,M;Magnani,JL;Blaszczyk,M;Steplewski,Z;Koprowski,H;Karlsson,KA;Larson,G;Ginsburg,V
通讯作者：
Ginsburg,V
由单克隆抗结肠癌抗体定义的路易斯血型抗原。
影响因子：
3.9
作者：
Blaszczyk,M;Hansson,GC;Karlsson,KA;Larson,G;Stromberg,N;Thurin,J;Herlyn,M;Steplewski,Z;Koprowski,H
通讯作者：
Koprowski,H