Concurrent tau pathologies in frontotemporal lobar degeneration with TDP-43 pathology.
Concurrent tau pathologies in frontotemporal lobar degeneration with TDP-43 pathology.
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DOI：
10.1111/nan.12778
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发表时间：
2022-03
影响因子：
5
通讯作者：
Dickson, Dennis W.
中科院分区：
文献类型：
--
作者：
Koga, Shunsuke;Zhou, Xiaolai;Murakami, Aya;Fernandez De Castro, Cristhoper;Baker, Matthew C.;Rademakers, Rosa;Dickson, Dennis W.
关键词：
Accumulating evidence suggests that patients with frontotemporal lobar degeneration (FTLD) can have pathologic accumulation of multiple proteins, including tau and TDP‐43. This study aimed to determine the frequency and characteristics of concurrent tau pathology in FTLD with TDP‐43 pathology (FTLD‐TDP). The study included 146 autopsy‐confirmed cases of FTLD‐TDP and 55 cases of FTLD‐TDP with motor neuron disease (FTLD‐MND). Sections from the basal forebrain were screened for tau pathology with phosphorylated‐tau immunohistochemistry. For cases with tau pathology on the screening section, additional brain sections were studied to establish a diagnosis. Genetic analysis of C9orf72, GRN and MAPT was performed on select cases. We found 72 cases (36%) with primary age‐related tauopathy (PART), 85 (42%) with ageing‐related tau astrogliopathy (ARTAG), 45 (22%) with argyrophilic grain disease (AGD) and 2 cases (1%) with corticobasal degeneration (CBD). Patients with ARTAG or AGD were significantly older than those without these comorbidities. One of the patients with FTLD‐TDP and CBD had C9orf72 mutation and relatively mild tau pathology, consistent with incidental CBD. The coexistence of TDP‐43 and tau pathologies was relatively common, particularly PART and ARTAG. Although rare, patients with FTLD can have multiple neurodegenerative proteinopathies. The absence of TDP‐43‐positive astrocytic plaques may suggest that CBD and FTLD‐TDP were independent disease processes in the two patients with both tau and TDP‐43 pathologies. It remains to be determined if mixed cases represent a unique disease process or two concurrent disease processes in an individual. By screening for tau pathology in 201 autopsy‐confirmed cases of frontotemporal lobar degeneration with TDP‐43 pathology (FTLD‐TDP), we found 85 patients (42%) with ageing‐related tau astrogliopathy (ARTAG) 72 (36%) with primary age‐related tauopathy (PART), 45 (22%) with argyrophilic grain disease (AGD) and 2 (1%) with corticobasal degeneration (CBD). Many of elderly individuals with neurodegenerative disorders have multiple coexisting pathologies; therefore, both TDP‐43 and tau should be included in the neuropathologic assessment of FTLD.
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影响因子：
5
作者：
Koga, Shunsuke;Zhou, Xiaolai;Dickson, Dennis W.
通讯作者：
Dickson, Dennis W.
影响因子：
16.2
作者：
Ash PE;Bieniek KF;Gendron TF;Caulfield T;Lin WL;Dejesus-Hernandez M;van Blitterswijk MM;Jansen-West K;Paul JW 3rd;Rademakers R;Boylan KB;Dickson DW;Petrucelli L
通讯作者：
Petrucelli L
DOI：
10.1007/s12031-011-9589-0
发表时间：
2011-11
期刊：
Journal of molecular neuroscience : MN
影响因子：
--
作者：
Dickson DW;Kouri N;Murray ME;Josephs KA
通讯作者：
Josephs KA
影响因子：
5.9
作者：
Koike Y;Sugai A;Hara N;Ito J;Yokoseki A;Ishihara T;Yamagishi T;Tsuboguchi S;Tada M;Ikeuchi T;Kakita A;Onodera O
通讯作者：
Onodera O
影响因子：
12.7
作者：
Kovacs GG;Ferrer I;Grinberg LT;Alafuzoff I;Attems J;Budka H;Cairns NJ;Crary JF;Duyckaerts C;Ghetti B;Halliday GM;Ironside JW;Love S;Mackenzie IR;Munoz DG;Murray ME;Nelson PT;Takahashi H;Trojanowski JQ;Ansorge O;Arzberger T;Baborie A;Beach TG;Bieniek KF;Bigio EH;Bodi I;Dugger BN;Feany M;Gelpi E;Gentleman SM;Giaccone G;Hatanpaa KJ;Heale R;Hof PR;Hofer M;Hortobágyi T;Jellinger K;Jicha GA;Ince P;Kofler J;Kövari E;Kril JJ;Mann DM;Matej R;McKee AC;McLean C;Milenkovic I;Montine TJ;Murayama S;Lee EB;Rahimi J;Rodriguez RD;Rozemüller A;Schneider JA;Schultz C;Seeley W;Seilhean D;Smith C;Tagliavini F;Takao M;Thal DR;Toledo JB;Tolnay M;Troncoso JC;Vinters HV;Weis S;Wharton SB;White CL 3rd;Wisniewski T;Woulfe JM;Yamada M;Dickson DW
通讯作者：
Dickson DW