A role for IgG immune complexes during infection with the intracellular pathogen Leishmania.
A role for IgG immune complexes during infection with the intracellular pathogen Leishmania.
复制标题
IgG免疫复合物在感染Leishmania的感染过程中的作用。
DOI：
10.1084/jem.20041470
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发表时间：
2005-03-07
影响因子：
15.3
通讯作者：
Mosser, DM
中科院分区：
文献类型：
--
作者：
Miles, SA;Conrad, SM;Aves, RG;Jeronimo, SMB;Mosser, DM
我们研究了免疫球蛋白（Ig）G抗体在介导宿主防御细胞内寄生虫利什曼原虫中的作用。我们发现IgG不仅不能提供对这种细胞内病原体的保护，而且它实际上有助于疾病的进展。BALB/c小鼠的JH株由于Ig重链(J)位点的靶向缺失而缺乏IgG，比正常BALB/c小鼠更能抵抗利什曼原虫感染。然而，被动给药抗利什曼IgG会导致JH小鼠出现含有大量寄生虫的大病变。抗体给药与病变中白细胞介素（IL） 10产生的增加相关，阻断小鼠IL-10受体可防止抗体介导的疾病恶化。在患有活动性内脏利什曼病的人类患者中，高IgG水平是疾病的预测指标。病程持续的患者IgG抗体滴度高，对利什曼原虫抗原无迟发性超敏反应（DTH）。这种模式在治疗后疾病消退后被逆转，导致总IgG降低，并伴有DTH反应性的逐渐增加。我们得出结论，IgG可以引起一种新的免疫增强形式，因为它能够诱导巨噬细胞产生IL-10。
We examined the role of immunoglobulin (Ig)G antibodies in mediating host defense to the intracellular parasite, Leishmania. We show that IgG not only fails to provide protection against this intracellular pathogen, but it actually contributes to disease progression. The JH strain of BALB/c mice, which lack IgG because they have a targeted deletion in the Ig heavy chain (J) locus, were more resistant to infection with Leishmania major than were normal BALB/c mice. However, the passive administration of anti-Leishmania IgG caused JH mice to develop large lesions containing high numbers of parasites. Antibody administration correlated with an increase in interleukin (IL) 10 production in lesions, and blocking the murine IL-10 receptor prevented antibody-mediated disease exacerbation. In human patients with active visceral leishmaniasis, high IgG levels are predictive of disease. Patients with ongoing disease had high IgG antibody titers and no delayed-type hypersensitivity (DTH) responses to Leishmania antigens. This pattern was reversed upon disease resolution after treatment, resulting in a decrease in total IgG, which was accompanied by a progressive increase in DTH responsiveness. We conclude that IgG can cause a novel form of immune enhancement due to its ability to induce IL-10 production from macrophages.
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DOI：
10.1083/jcb.123.3.759
发表时间：
1993-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Love DC;Esko JD;Mosser DM
通讯作者：
Mosser DM
影响因子：
1.8
作者：
Quinnell, RJ;Courtenay, O;Day, MJ
通讯作者：
Day, MJ
影响因子：
64.8
作者：
HALSTEAD, SB;OROURKE, EJ
通讯作者：
OROURKE, EJ
影响因子：
11.4
作者：
O'Farrell, AM;Liu, Y;Mui, ALF
通讯作者：
Mui, ALF
影响因子：
6.4
作者：
EVANS, TG;TEIXEIRA, MJ;PEARSON, RD
通讯作者：
PEARSON, RD