Measles immunity and immunosuppression.
Measles immunity and immunosuppression.
复制标题
麻疹免疫和免疫抑制。
DOI：
10.1016/j.coviro.2020.08.002
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发表时间：
2021-03
影响因子：
5.9
通讯作者：
Griffin DE
中科院分区：
文献类型：
--
作者：
Griffin DE
麻疹病毒在淋巴组织中的复制使用CD150作为B细胞和T细胞受体。淋巴组织中的持久性RNA与持久免疫的产生有关。生发中心和外周Tfh细胞和抗体分泌细胞的数量在几个月内增加。明显康复后，对其他感染的易感性会持续数年。记忆和naïve B细胞被耗尽，原有抗体的多样性减少。麻疹对免疫系统的影响目前还不完全清楚。淋巴组织是麻疹病毒（MeV）复制的主要部位，其中CD150是B细胞和T细胞感染的受体。淋巴细胞耗竭发生在感染的急性期，但适应性免疫反应的启动导致广泛的淋巴细胞增殖、mev特异性抗体和T细胞的产生、皮疹和传染性病毒的清除。病毒RNA持续存在于淋巴组织中，伴随着生发中心的增殖、抗体分泌细胞的产生、功能不同的T细胞群和抗体贪婪的成熟，以建立终身免疫。然而，与此同时，预先存在的抗体的多样性以及记忆和幼稚B细胞的数量减少，对其他感染的易感性增加。
Measles virus replication in lymphoid tissue uses CD150 as a B and T cell receptor. Persistent RNA in lymphoid tissue is associated with generation of durable immunity. Germinal centers and numbers of peripheral Tfh cells and antibody-secreting cells increase for months. Increased susceptibility to other infections continues for years after apparent recovery. Memory and naïve B cells are depleted and diversity of pre-existing antibodies is reduced. Effects of measles on the immune system are only partially understood. Lymphoid tissue is a primary site of measles virus (MeV) replication where CD150 is the receptor for infection of both B and T cells. Lymphocyte depletion occurs during the acute phase of infection, but initiation of the adaptive immune response leads to extensive lymphocyte proliferation, production of MeV-specific antibody and T cells, the rash and clearance of infectious virus. Viral RNA persists in lymphoid tissue accompanied by ongoing germinal center proliferation, production of antibody-secreting cells, functionally distinct populations of T cells and antibody avidity maturation to establish life-long immunity. However, at the same time diversity of pre-existing antibodies and numbers of memory and naive B cells are reduced and susceptibility to other infections is increased.
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影响因子：
158.5
作者：
ENDERS, JF;MCCARTHY, K;CHEATHAM, WJ
通讯作者：
CHEATHAM, WJ
影响因子：
2.9
作者：
Gadroen K;Dodd CN;Masclee GMC;de Ridder MAJ;Weibel D;Mina MJ;Grenfell BT;Sturkenboom MCJM;van de Vijver DAMC;de Swart RL
通讯作者：
de Swart RL
影响因子：
3.6
作者：
Behrens, Lynn;Cherry, James D.;Heininger, Ulrich
通讯作者：
Heininger, Ulrich
影响因子：
6.7
作者：
de Vries RD;McQuaid S;van Amerongen G;Yüksel S;Verburgh RJ;Osterhaus AD;Duprex WP;de Swart RL
通讯作者：
de Swart RL
影响因子：
11.4
作者：
Dispenzieri A;Tong C;LaPlant B;Lacy MQ;Laumann K;Dingli D;Zhou Y;Federspiel MJ;Gertz MA;Hayman S;Buadi F;O'Connor M;Lowe VJ;Peng KW;Russell SJ
通讯作者：
Russell SJ