Cardiovascular magnetic resonance characterization of rheumatic mitral stenosis: findings from three worldwide endemic zones.
Cardiovascular magnetic resonance characterization of rheumatic mitral stenosis: findings from three worldwide endemic zones.
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DOI：
10.1186/s12968-022-00853-5
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发表时间：
2022-04-07
期刊：
影响因子：
--
通讯作者：
Han Y
中科院分区：
文献类型：
--
作者：
Vidula MK;Xu Z;Xu Y;Alturki A;Reddy BN;Kini P;Alberto-Delgado AL;Jacob R;Chen T;Ferrari VA;Sierra-Galan LM;Chen Y;Viswamitra S;Han Y
风湿性二尖瓣狭窄（MS）的心脏重构是复杂且不完全了解的。本研究的目的是利用心血管磁共振（CMR）评估一组风湿性MS患者的心脏结构和功能变化。本回顾性研究纳入了40例风湿性MS患者，其中19例来自印度，15例来自中国，6例来自墨西哥(中位（四分位间距（IQR））年龄：45岁（34-55岁）；75%的女性)。对照组20例。收集有关形态和功能的CMR变量。获得晚期钆增强（LGE）序列用于组织表征。采用Kruskal-Wallis检验和卡方检验进行统计分析。与对照组相比，MS患者左室射血分数较低(51% (42%-55%)vs 60%(57%-65%)，右室射血分数较低(44% (40%-52%)vs 64% (59%-67%), p < 0.001)，左室舒张末期容积较高(72 (58-87)mL/m2 vs 59 (49-69) mL/m2, p = 0.003)，左心房容积较大(87 (67-108)mL/m2 vs 29 (22-34) mL/m2, p < 0.001)，右心房面积(20 （16-23)cm2 vs 13 (12-16) cm2, p < 0.001）。LGE在风湿性MS患者中普遍存在（82%），通常位于右心室插入部位。此外，来自印度、中国和墨西哥的患者队列在基线特征和心脏重构方面存在异质性。我们的研究结果表明，双心室功能障碍、左右心房重构和左心室插入部位的LGE在当代风湿性ms中被低估了，需要进一步的研究来阐明这些发现的预后意义。在线版本包含补充材料，可在10.1186/s12968-022-00853-5获得。
Cardiac remodeling in rheumatic mitral stenosis (MS) is complex and incompletely understood. The objective of this study was to evaluate cardiac structural and functional changes in a cohort of patients with rheumatic MS using cardiovascular magnetic resonance (CMR). This retrospective study included 40 patients with rheumatic MS, consisting of 19 patients from India, 15 patients from China, and 6 patients from Mexico (median (interquartile range (IQR)) age: 45 years (34–55); 75% women). Twenty patients were included in the control group. CMR variables pertaining to morphology and function were collected. Late gadolinium enhancement (LGE) sequences were acquired for tissue characterization. Statistical analyses were performed using the Kruskal–Wallis test and the chi-square test. Compared to the control group, patients with MS had lower left ventricular (LV) ejection fraction (51% (42%–55%) vs 60% (57%–65%), p < 0.001), lower right ventricular (RV) ejection fraction (44% (40%–52%) vs 64% (59%–67%), p < 0.001), higher RV end-diastolic volume (72 (58–87) mL/m2 vs 59 (49–69) mL/m2, p = 0.003), larger left atrial volume (87 (67–108) mL/m2 vs 29 (22–34) mL/m2, p < 0.001), and right atrial areas (20 (16–23) cm2 vs 13 (12–16) cm2, p < 0.001). LGE was prevalent in patients with rheumatic MS (82%), and was commonly located at the RV insertion sites. Furthermore, the patient cohorts from India, China, and Mexico were heterogeneous in terms of baseline characteristics and cardiac remodeling. Our findings demonstrated that biventricular dysfunction, right and left atrial remodeling, and LGE at the RV insertion sites are underappreciated in contemporary rheumatic MS. Further studies are needed to elucidate the prognostic implications of these findings. The online version contains supplementary material available at 10.1186/s12968-022-00853-5.
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DOI：
10.2214/ajr.09.4114
发表时间：
2011-01
期刊：
AJR. American journal of roentgenology
影响因子：
--
作者：
Shehata ML;Lossnitzer D;Skrok J;Boyce D;Lechtzin N;Mathai SC;Girgis RE;Osman N;Lima JA;Bluemke DA;Hassoun PM;Vogel-Claussen J
通讯作者：
Vogel-Claussen J
影响因子：
2.8
作者：
Sanz, Javier;Dellegrottaglie, Santo;Rajagopalan, Sanjay
通讯作者：
Rajagopalan, Sanjay
影响因子：
37.8
作者：
KELLY, DT;SPOTNITZ, HM;EPSTEIN, SE
通讯作者：
EPSTEIN, SE
影响因子：
37.8
作者：
MCKAY, CR;KAWANISHI, DT;RAHIMTOOLA, SH
通讯作者：
RAHIMTOOLA, SH
影响因子：
24
作者：
Djavidani, B;Debl, K;Luchner, A
通讯作者：
Luchner, A