Comprehensive insight into endothelial progenitor cell-derived extracellular vesicles as a promising candidate for disease treatment.
Comprehensive insight into endothelial progenitor cell-derived extracellular vesicles as a promising candidate for disease treatment.
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DOI：
10.1186/s13287-022-02921-0
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发表时间：
2022-06-07
影响因子：
7.5
通讯作者：
中科院分区：
文献类型：
--
作者：
内皮祖细胞（Endothelial progenitor cells，EPCs）是一种干细胞，具有很强的血管生成和组织修复能力。细胞外囊泡（extracellular vesicles，EVs）含有多种有效成分，如细胞蛋白质、microRNA、信使RNA和长链非编码RNA，可由不同类型的细胞分泌。EV的功能主要依赖于其亲本细胞。许多研究人员对EPC衍生的EV（EPC-EV）进行了功能研究，并显示它们对许多疾病表现出治疗作用，例如心血管疾病、急性肾损伤、急性肺损伤和败血症。本文就EPCs和EVs的生物学起源、功能以及EPC-EVs在治疗多种疾病中的作用进行综述。此外，还讨论了目前存在的问题和未来的前景，需要进一步研究来比较各种干细胞衍生的EV的治疗效果，这将有助于加速这些应用在临床环境中的转化。在线版本包含补充材料，可通过10.1186/s13287-022-02921-0获得。
Endothelial progenitor cells (EPCs), which are a type of stem cell, have been found to have strong angiogenic and tissue repair capabilities. Extracellular vesicles (EVs) contain many effective components, such as cellular proteins, microRNAs, messenger RNAs, and long noncoding RNAs, and can be secreted by different cell types. The functions of EVs depend mainly on their parent cells. Many researchers have conducted functional studies of EPC-derived EVs (EPC-EVs) and showed that they exhibit therapeutic effects on many diseases, such as cardiovascular disease, acute kidney injury, acute lung injury, and sepsis. In this review article, we comprehensively summarized the biogenesis and functions of EPCs and EVs and the potent role of EPC-EVs in the treatment of various diseases. Furthermore, the current problems and future prospects have been discussed, and further studies are needed to compare the therapeutic effects of EVs derived from various stem cells, which will contribute to the accelerated translation of these applications in a clinical setting. The online version contains supplementary material available at 10.1186/s13287-022-02921-0.
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