High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults.
High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults.
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DOI：
10.1111/jpi.12801
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发表时间：
2022-08
影响因子：
10.3
通讯作者：
中科院分区：
文献类型：
--
作者：
衰老与睡眠的变化有关，改善睡眠可能对老年人的健康，认知和生活质量产生重要影响。许多处方睡眠辅助剂增加了夜间福尔斯的风险，对第二天的认知有不良影响，并与死亡率增加有关。褪黑激素是一种在夜间分泌的激素，可以增加年轻人的睡眠时间，但只有在内源性水平较低的白天服用时才能增加睡眠时间。在一项为期一个月的交叉研究中，我们将24名健康的老年人（年龄>55岁，平均年龄64.2 ± 6.3岁）随机分为两组，分别接受两周的安慰剂和两周的低剂量（0.3 mg）或高剂量（5.0 mg）褪黑激素。睡眠被多导睡眠描记器记录，并在生物白天和夜间使用强迫desperry设计。虽然0.3毫克褪黑激素总体上有提高睡眠效率的趋势，但这是由于它在生物日期间对睡眠的影响。相比之下，5毫克褪黑激素在生物白天和夜晚都显著增加了睡眠效率，主要是通过增加第2阶段非REM睡眠的持续时间和略微缩短觉醒时间。褪黑激素应进一步探索作为老年人的睡眠援助。
Aging is associated with changes in sleep, and improving sleep may have important consequences for the health, cognition, and quality of life of older adults. Many prescription sleep aids increase the risk of nighttime falls, have adverse effects on next-day cognition, and are associated with increased mortality. Melatonin, a hormone secreted at night, increases sleep duration in young adults but only when administered during the day when endogenous levels are low. In a month-long cross-over study, we randomized 24 healthy older (age >55, mean 64.2 ± 6.3 years) participants to receive two weeks of placebo and two weeks of either a low (0.3 mg) or high (5.o mg) dose of melatonin 30 minutes before sleep. Sleep was polysomnographically recorded and was scheduled during both the biological day and night using a forced desynchrony design. While 0.3 mg melatonin had a trend towards increasing sleep efficiency overall, this was due to it’s effects on sleep during the biological day. In contrast, 5 mg melatonin significantly increased sleep efficiency during both biological day and night, mainly by increasing the duration of stage 2 nonREM sleep and slightly shortening awakenings. Melatonin should be further explored as a sleep aid for older adults.
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DOI：
10.1073/pnas.1010666108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Duffy, Jeanne F.;Cain, Sean W.;Czeisler, Charles A.
通讯作者：
Czeisler, Charles A.
DOI：
10.1136/bmj.g5205
发表时间：
2014-09-09
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Billioti de Gage S;Moride Y;Ducruet T;Kurth T;Verdoux H;Tournier M;Pariente A;Bégaud B
通讯作者：
Bégaud B
影响因子：
2.7
作者：
Khachiyants N;Trinkle D;Son SJ;Kim KY
通讯作者：
Kim KY
DOI：
10.1038/nrneurol.2013.269
发表时间：
2014-02
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.8
作者：
FOLSTEIN, MF;FOLSTEIN, SE;MCHUGH, PR
通讯作者：
MCHUGH, PR