Sundown syndrome in persons with dementia: an update.
Sundown syndrome in persons with dementia: an update.
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DOI：
10.4306/pi.2011.8.4.275
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发表时间：
2011-12
影响因子：
2.7
通讯作者：
Kim KY
中科院分区：
文献类型：
--
作者：
Khachiyants N;Trinkle D;Son SJ;Kim KY
痴呆患者的“日落”作为一种独特的临床现象，在明确的定义、病因、可操作的参数、临床结构的有效性和干预措施等方面仍存在争议。一般来说，日落综合症的特征是神经精神症状的出现或增加，如在下午晚些时候、晚上或晚上出现或增加焦虑、困惑、焦虑和攻击性。日落在痴呆症患者中非常普遍。它被认为与昼夜节律受损、环境和社会因素以及认知受损有关。神经生理学上，它似乎是通过下丘脑视交叉上核的退化和褪黑素的减少来调节的。已发现多种治疗方案有助于改善与此现象相关的神经精神症状：强光疗法、褪黑素、乙酰胆碱酯酶抑制剂、N-甲基-D-天冬氨酸受体拮抗剂、抗精神病药物和行为改变。为了减少这种特殊情况的发病率，改善患者的幸福感，减轻照顾者的负担，并延迟住院，需要进一步关注日落综合征的临床操作定义的发展，以及对病因、危险因素和有效治疗方案的研究。
"Sundowning" in demented individuals, as distinct clinical phenomena, is still open to debate in terms of clear definition, etiology, operationalized parameters, validity of clinical construct, and interventions. In general, sundown syndrome is characterized by the emergence or increment of neuropsychiatric symptoms such as agitation, confusion, anxiety, and aggressiveness in late afternoon, in the evening, or at night. Sundowning is highly prevalent among individuals with dementia. It is thought to be associated with impaired circadian rhythmicity, environmental and social factors, and impaired cognition. Neurophysiologically, it appears to be mediated by degeneration of the suprachiasmatic nucleus of the hypothalamus and decreased production of melatonin. A variety of treatment options have been found to be helpful to ameliorate the neuropsychiatric symptoms associated with this phenomenon: bright light therapy, melatonin, acetylcholinesterase inhibitors, N-methyl-d-aspartate receptor antagonists, antipsychotics, and behavioral modifications. To decrease the morbidity from this specific condition, improve patient's well being, lessen caregiver burden, and delay institutionalization, further attention needs to be given to development of clinically operational definition of sundown syndrome and investigations on etiology, risk factors, and effective treatment options.
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影响因子：
3.1
作者：
Ancoli-Israel, Sonia;Gehrman, Philip;Levi, Leah
通讯作者：
Levi, Leah
DOI：
10.1176/appi.neuropsych.15.3.363
发表时间：
2003-06-01
影响因子：
2.9
作者：
Balan, S;Leibovitz, A;Habot, B
通讯作者：
Habot, B
影响因子：
2.6
作者：
Bliwise, DL;Rye, DB;Gurecki, P
通讯作者：
Gurecki, P
DOI：
10.1159/000107035
发表时间：
1992-09-01
期刊：
DEMENTIA
影响因子：
--
作者：
BLIWISE, DL;YESAVAGE, JA;TINKLENBERG, JR
通讯作者：
TINKLENBERG, JR
影响因子：
2.6
作者：
BLIWISE, DL;WATTS, RL;HUGHES, M
通讯作者：
HUGHES, M