Autophagy in photodynamic therapy

Autophagy in photodynamic therapy
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光动力疗法中的自噬

DOI:
10.4314/tjpr.v15i4.31
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发表时间:
2016-05
影响因子:
0.6
通讯作者:
田媛媛
田媛媛
中科院分区:
医学4区
文献类型:
--
作者:
梁黎明;毕文祥;田媛媛

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巨噬(autophagy)是细胞在饥饿状态下存活的关键,在人类疾病中起着重要作用。在真核生物中,它是一个高度保守的细胞内降解系统,用于去除和回收细胞质成分,包括受损的蛋白质和细胞器,以获得能量。近年来,肿瘤与自噬的关系得到了广泛的研究。在癌症和癌症治疗中,自噬是一把双刃剑。光动力疗法(PDT)是一种应用肿瘤定位光敏剂,然后用特定波长的光激活的肿瘤治疗方法。光动力疗法中自噬作用有多大?这方面的工作仍然有限。
Macroautophagy (autophagy) is crucial for cell survival during starvation and plays important roles in human diseases. It is a highly conserved intracellular degradation system in eukaryotes for removal and recycling of cytoplasmic components including damaged proteins and organelles to obtain energy. The relationship between cancer and autophagy has been extensively studied in recent years. In cancer and cancer therapy, autophagy acts as a double-edged sword. Photodynamic therapy (PDT) is a kind of tumor therapy applied with a tumor-localizing photosensitizing agent which is followed by activation with the light of a specific wavelength. How much is autophagy involved in photodynamic therapy? The work in this area is still limited.
DOI: 10.1016/j.tiv.2009.08.015
发表时间: 2010-02
期刊: Toxicology in vitro : an international journal published in association with BIBRA
影响因子: --
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