Age exacerbates the effect of myopia on retinal capillaries and string vessels.
Age exacerbates the effect of myopia on retinal capillaries and string vessels.
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DOI：
10.3389/fmed.2023.1112396
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发表时间：
2023
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
视网膜血管系统为细胞提供氧气和营养，对视网膜功能的正常发挥至关重要。在近视中，过度的眼睛生长与各种可能导致近视相关并发症的解剖变化有关。然而，近视引起的眼部生长如何在细胞水平上影响老年视网膜微血管的完整性尚不清楚。在这里，我们研究了衰老如何与14只狨猴视网膜（Callithrix jacchus）近视引起的视网膜微血管改变相互作用。对视网膜4个毛细血管丛的细血管和毛细血管支点进行成像和定量。随着晶状体性近视狨猴年龄的增长，它们在所有四个血管丛中都出现了越来越多的束状血管，中央凹旁和乳头周围视网膜的血管分支点增加，而周围视网膜的血管分支点减少。这些近视引起的视网膜微血管的变化表明视网膜微血管细胞结构模板随着年龄的增长和近视的发展和进展而发生适应性重组。
The retinal vasculature supplies oxygen and nutrition to the cells and is crucial for an adequate retinal function. In myopia, excessive eye growth is associated with various anatomical changes that can lead to myopia-related complications. However, how myopia-induced ocular growth affects the integrity of the aged retinal microvasculature at the cellular level is not well understood. Here, we studied how aging interacts with myopia-induced alteration of the retinal microvasculature in fourteen marmoset retinas (Callithrix jacchus). String vessel and capillary branchpoint were imaged and quantified in all four capillary plexi of the retinal vasculature. As marmosets with lens-induced myopia aged, they developed increasing numbers of string vessels in all four vascular plexi, with increased vessel branchpoints in the parafoveal and peripapillary retina and decreased vessel branchpoints in the peripheral retina. These myopia-induced changes to the retinal microvasculature suggest an adaptive reorganization of the retinal microvascular cellular structure template with aging and during myopia development and progression.
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影响因子：
4.4
作者：
Al-Sheikh, Mayss;Phasukkijwatana, Nopasak;Sarraf, David
通讯作者：
Sarraf, David
影响因子：
3.4
作者：
Chakraborty, Ranjay;Read, Scott A.;Collins, Michael J.
通讯作者：
Collins, Michael J.
影响因子：
4.2
作者：
Castellani, RJ;Smith, MA;Friedland, RP
通讯作者：
Friedland, RP
影响因子：
3.3
作者：
Bussière, T;Gold, G;Hof, PR
通讯作者：
Hof, PR
影响因子：
4.6
作者：
Ehling, Manuel;Adams, Susanne;Adams, Ralf H.
通讯作者：
Adams, Ralf H.