Peritoneal transport physiology: insights from basic research.
Peritoneal transport physiology: insights from basic research.
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腹膜运输生理学：基础研究的见解。
DOI：
--
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发表时间：
1991
影响因子：
13.6
通讯作者：
Michael F. Flessner
中科院分区：
文献类型：
--
作者：
Michael F. Flessner
腹膜腔的临床应用，如腹膜内化疗或腹膜透析，取决于血液和腹膜腔之间运输的潜在生理机制。腹膜转运的临床模型集中于理想化的“腹膜”。“然而，这样的膜实际上并不存在。转运实际上发生在腹膜腔和血液之间，血液包含在分布在腔周围的组织结缔组织中的离散毛细血管中。为了整合毛细血管和微血管的性质，“分布式模型”方法将模拟跨内皮运输的孔理论与组织空间内的扩散和对流耦合。分布理论可以解释为什么腹膜与人工肾相比，对尿素表现为紧而对蛋白质表现为漏。对尿素转运的额外阻力归因于腹膜附近的“未搅拌层”。现在可以通过检查组织间隙中的扩散来生理地定义这些。对流进出腔的绝对速率尚不能准确预测，但可以指定生理力。透析过程中的净“超滤”不仅来自腹膜透析液中的高渗透压，还来自小但显著的流体静压，其驱动相反方向的对流。最近的蛋白质吸收研究表明，反渗透剂是净超滤减少的原因，这只是部分正确的。对组织间隙数据的分析表明，蛋白质从腔体沉积到组织中，并缓慢吸收到组织中。
Clinical uses of the peritoneal cavity, such as i.p. chemotherapy or peritoneal dialysis, depend on underlying physiological mechanisms of transport between the blood and the peritoneal cavity. Clinical models of peritoneal transport have focused on an idealized "peritoneal membrane." However, such a membrane does not physically exist. Transport actually occurs between the peritoneal cavity and blood which is contained in discrete capillaries distributed in the tissue interstitium surrounding the cavity. To integrate the properties of the capillaries and the interstitium, the "distributed model" approach couples pore theory, which simulates transendothelial transport, with diffusion and convection within the tissue space. The distributed theory can explain why the peritoneal membrane, when compared with the artificial kidney, appears tight to urea but leaky to protein. The additional resistance to urea transport has been attributed to "unstirred layers" adjacent to the peritoneal membrane. These can now be defined physiologically by examining diffusion in the tissue space. Absolute rates of convection into and out of the cavity cannot yet be accurately predicted, but the physiological forces can be specified. Net "ultrafiltration" during dialysis results from not only high osmotic pressure in the peritoneal dialysate but also from a small but significant hydrostatic pressure which drives convection in the opposite direction. Recent implications from protein absorption studies that lymphatics are the cause of the decrease in net ultrafiltration are only partly true. Analysis of data from the tissue space has shown that the deposition of protein occurs from the cavity into the tissue interstitium with a slow uptake into lymphatics.
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影响因子：
3.1
作者：
Rippe,B;Perry,MA;Granger,DN
通讯作者：
Granger,DN
抗体在小鼠体内生长的实验性人类实体瘤中的渗透和结合。
影响因子：
11.2
作者：
Ong,GL;Mattes,MJ
通讯作者：
Mattes,MJ
静脉压升高对肌肉中白蛋白和 IgG 排除体积的影响。
DOI：
10.1152/ajpheart.1982.242.6.h1044
发表时间：
1982
期刊：
The American journal of physiology
影响因子：
--
作者：
Bell,DR;Mullins,RJ
通讯作者：
Mullins,RJ
DOI：
10.1152/ajpheart.1980.239.4.h532
发表时间：
1980
期刊：
The American journal of physiology
影响因子：
--
作者：
Bell,DR;Watson,PD;Renkin,EM
通讯作者：
Renkin,EM