Mild calorie restriction induces fat accumulation in female C57BL/6J mice.
Mild calorie restriction induces fat accumulation in female C57BL/6J mice.
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DOI：
10.1038/oby.2009.312
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发表时间：
2010-03
期刊：
影响因子：
6.9
通讯作者：
Nagy, Tim R.
中科院分区：
文献类型：
--
作者：
Li, Xingsheng;Cope, Mark B.;Johnson, Maria S.;Smith, Daniel L., Jr.;Nagy, Tim R.
本研究探讨了轻度热量限制（5%）对雌性C57 BL/6 J小鼠体重、体成分、能量消耗、摄食行为和自发活动的影响。相对于随意小鼠的基线摄入量，使小鼠的食物摄入量减少5%，持续3或4周。在实验1中，每周监测体重，并在第0、2和4周通过双能X射线吸收测定法测定身体组成（脂肪和瘦体重）。在实验2中，每3天测量一次体重，每周通过定量磁共振测定身体组成，并在代谢室中测定3周内的能量消耗、摄食行为和自发活动。在两个实验结束时，CR小鼠与AL小鼠相比具有更大的脂肪质量（P < 0.01）和更少的瘦质量（P < 0.01）。CR组小鼠的总能量消耗（P < 0.05）和静息能量消耗（P < 0.05）均显著低于AL组小鼠。CR小鼠在1600小时后立即进食显著多于AL小鼠（P < 0.01）。这些结果表明，轻度CR导致雌性C57 BL/6 J小鼠脂肪量增加，瘦体重和能量消耗减少，并改变了摄食行为。运动活动或BAT产热能力似乎没有导致能量消耗的减少。脂肪量的增加和瘦体重的减少可能是对食物供应不确定性的应激反应。
This study investigated the effects of mild calorie restriction (5%) on body weight, body composition, energy expenditure, feeding behavior, and locomotor activity in female C57BL/6J mice. Mice were subjected to a 5% reduction of food intake relative to baseline intake of ad libitum mice for 3 or 4 weeks. In experiment 1, body weight was monitored weekly and body composition (fat and lean mass) was determined at weeks 0, 2, and 4 by dual-energy X-ray absorptiometry. In experiment 2, body weight was measured every 3 days and body composition was determined by quantitative magnetic resonance weekly, and energy expenditure, feeding behavior, and locomotor activity were determined over 3 weeks in a metabolic chamber. At the end of both experiments, CR mice had greater fat mass (P < 0.01) and less lean mass (P < 0.01) compared with AL mice. Total energy expenditure (P < 0.05) and resting energy expenditure (P < 0.05) were significantly decreased in CR mice compared with AL mice over 3 weeks. CR mice ate significantly more food than AL mice immediately following daily food provisioning at 1600 hrs (P < 0.01). These findings showed that mild CR caused increased fat mass, decreased lean mass and energy expenditure, and altered feeding behavior in female C57BL/6J mice. Locomotor activity or BAT thermogenic capacity did not appear to contribute to the decrease in energy expenditure. The increase in fat mass and decrease in lean mass may be a stress response to the uncertainty of food availability.
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影响因子：
7.1
作者：
NELSON, KM;WEINSIER, RL;SCHUTZ, Y
通讯作者：
SCHUTZ, Y
DOI：
10.1038/oby.2002.73
发表时间：
2002-06-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Powell, CS;Blaylock, ML;Nagy, TR
通讯作者：
Nagy, TR
影响因子：
4
作者：
Escriva, Fernando;Gavete, M. Lucia;Carrascosa, Jose M.
通讯作者：
Carrascosa, Jose M.
影响因子：
5.3
作者：
DUFFY, PH;FEUERS, RJ;HART, RW
通讯作者：
HART, RW
影响因子：
4.8
作者：
Martin, Bronwen;Pearson, Michele;Mattson, Mark P.
通讯作者：
Mattson, Mark P.