Anaplastic Large T-Cell Lymphoma in the Intestine of Dogs.
Anaplastic Large T-Cell Lymphoma in the Intestine of Dogs.
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DOI：
10.1177/0300985819852132
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发表时间：
2019-11
影响因子：
2.4
通讯作者：
Oliveira F
中科院分区：
文献类型：
--
作者：
Stranahan LW;Whitley D;Thaiwong T;Kiupel M;Oliveira F
间变性大t细胞淋巴瘤（ALTCL）是一种罕见的非霍奇金t细胞淋巴瘤亚型，偶尔发生在人类胃肠道。肠病相关t细胞淋巴瘤（Enteropathy-associated T-cell lymphoma， EATL） 1型是犬中最常见的肠道淋巴瘤，而ALTCL在犬的肠道中尚未见报道。本文回顾了13例肠肿块诊断为肠淋巴瘤伴间变性形态的犬。包括治疗方案在内的11例临床资料均可获得。对所有病例进行CD3、CD20和CD30的免疫组织化学检测，并对抗原受体重排（PARR）进行PCR检测以评估克隆性。8例（62%）表现为肠道穿孔，所有病例均有1个或更多的小肠肿块。组织学上，所有病例均表现为大的、cd3阳性和cd30阳性细胞的跨壁浸润。肿瘤T细胞有明显的异细胞增多和异核症，核仁突出，偶尔有缩进到肾形核。肿瘤肿块内有大量坏死和炎症，偶有血管浸润。所有病例均有单克隆t细胞受体γ基因重排。中位生存时间为5天，其中1只犬在初次诊断后存活了2年。ALTCL可作为犬胃肠道的侵袭性跨壁淋巴瘤发生，通常导致肠道穿孔。ALTCL可以与1型EATL区分开来，这可能对未来准确的预后和治疗方案的选择有影响。
Anaplastic large T-cell lymphoma (ALTCL) is a rare subtype of non-Hodgkin T-cell lymphoma that occasionally occurs in the gastrointestinal tract of humans. Enteropathy-associated T-cell lymphoma (EATL) type 1 is the most common type of intestinal lymphoma in dogs, and ALTCL has not previously been reported in the intestinal tract of dogs. Thirteen dogs with intestinal masses diagnosed as intestinal lymphoma with anaplastic morphology were reviewed. Clinical data, including treatment protocols, were available for 11 cases. Immunohistochemistry for CD3, CD20, and CD30 was performed for all cases in addition to PCR for Antigen Receptor Rearrangements (PARR) for assessment of clonality. Eight (62%) of the cases presented with intestinal perforation, and all cases had 1 or more masses arising from the small intestine. Histologically, all cases were characterized by transmural infiltrates of large, CD3-positive and frequently CD30-positive cells. Neoplastic T cells had marked anisocytosis and anisokaryosis, prominent nucleoli, and occasionally indented to reniform nuclei. There was abundant necrosis and inflammation with occasional vascular invasion within neoplastic masses. All cases had a monoclonal T-cell receptor γ gene rearrangement. The median survival time was 5 days, with 1 dog surviving 2 years after the initial diagnosis. ALTCL can occur as an aggressive transmural lymphoma in the gastrointestinal tract of dogs and commonly causes intestinal perforation. ALTCL can be differentiated from EATL type 1 and might have implications for accurate prognostication and selection of therapeutic options in the future.
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影响因子：
2.6
作者：
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通讯作者：
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