Effect of thymosin immunostimulation with and without corticosteroid immunosuppression on chimpanzee hepatitis B carriers.
Effect of thymosin immunostimulation with and without corticosteroid immunosuppression on chimpanzee hepatitis B carriers.
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胸腺素免疫刺激联合或不联合皮质类固醇免疫抑制对黑猩猩乙型肝炎携带者的影响。
DOI：
10.1002/jmv.1890210105
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发表时间：
1987
影响因子：
12.7
通讯作者：
Langloss,JM
中科院分区：
文献类型：
--
作者：
Eichberg,JW;Seeff,LB;Lawlor,DL;Buskell-Bales,Z;Ishak,K;Hoofnagle,JH;Goldstein,AL;Langloss,JM
Carriers of hepatitis B surface antigen (HBsAg) are at a high personal risk of developing chronic hepatitis, cirrhosis, and primary hepatocellular carcinoma, and they pose a potential health threat to others. Accordingly, erradication of the carrier state is an important therapeutic goal. Several categories of drugs have been evaluated for this purpose, with, at best, limited success. The immune stimulants constitute a drug group considered to have potential benefit, since altered cell‐mediated immunity (CMI) appears to have a pathogenic role in the perpetuation of the carrier state. One such immune stimulant is the thymic hormone, thymosin, which is known to enhance suppressor T‐cell activity. We therefore examined its possible therapeutic role by evaluating its effect on four chronic HBsAg‐ and hepatitis B e antigen (HBeAg)‐positive chimpanzees. After baseline biochemical, serological, immunological, and histochemical studies were conducted, all four chimpanzees received parenteral thymosin for a period of 10–14 weeks; two of them were pretreated for 4 weeks with corticosteroids. All four were then reevaluated in the same manner at regular intervals during the 14‐week period. Neither immunosuppression nor immunostimulation significantly affected biochemical, serological, or histological measures. Indices of CMI were altered, however: both T4 and T8 cells increased with thymosin treatment, although the T4/T8 ratio declined because of the relatively greater increase of the T8 than of the T4 cells. Thymosin did not affect the mitogen assays. Thus, while immunostimulation with thymosin did slightly alter CMI, it had no affect on the HBsAg carrier state or on measures of chronic hepatitis, even when preceded by corticosteroid immunosuppression.
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影响因子：
56.9
作者：
LEDOUARIN, NM
通讯作者：
LEDOUARIN, NM
脊髓早期部分逆转后小鸡后肢的运动神经元投射模式。
DOI：
10.1113/jphysiol.1980.sp013262
发表时间：
1980
期刊：
The Journal of Physiology
影响因子：
--
作者：
C. Lance‐Jones;L. Landmesser
通讯作者：
L. Landmesser
外周通路是由蚱蜢胚胎中的一系列中枢和外周神经元开创的
影响因子：
64.8
作者：
R. Ho;C. Goodman
通讯作者：
C. Goodman
DOI：
--
发表时间：
1975
期刊：
Journal of Physiology
影响因子：
--
作者：
BY Lynn Landmesser;D. G. Morris
通讯作者：
D. G. Morris
神经中枢减少对鸡胚翅膀中残余神经节发育和神经模式的影响。
影响因子：
--
作者：
G. D. O. Castro
通讯作者：
G. D. O. Castro