The genetic variation in the R1a clade among the Ashkenazi Levites' Y chromosome.
The genetic variation in the R1a clade among the Ashkenazi Levites' Y chromosome.
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DOI：
10.1038/s41598-017-14761-7
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发表时间：
2017-11-02
影响因子：
4.6
通讯作者：
Villems R
中科院分区：
文献类型：
--
作者：
Behar DM;Saag L;Karmin M;Gover MG;Wexler JD;Sanchez LF;Greenspan E;Kushniarevich A;Davydenko O;Sahakyan H;Yepiskoposyan L;Boattini A;Sarno S;Pagani L;Carmi S;Tzur S;Metspalu E;Bormans C;Skorecki K;Metspalu M;Rootsi S;Villems R
地球仪上大约有30万人自认为是德系犹太利未人，其中三分之二以前被证明是一个男性的后代。由于缺乏完整的Y染色体序列，无法确定这一祖先的年龄、地理来源和迁移模式。在这里，我们报告的德系和非德系利未人R1 a分支，其他德系犹太父系血统，以及非利未人犹太人和非犹太人R1 a样本内的486 Y染色体的变化。累积起来，新出现的档案是一个中东祖先，自我隶属为利未人，并携带高度解析的R1 a-Y2619谱系，这可能是希伯来人中的一个次要单倍群。一个类似于其他德系犹太人父系谱系的星型祖先，约1,743年前，表明它是德系犹太人父系的创始人之一;作为整个德系犹太人人口扩张的一部分而扩张，与利未人的关系没有特殊关系;随后传播到非德系犹太人的利未人。
Approximately 300,000 men around the globe self-identify as Ashkenazi Levites, of whom two thirds were previously shown to descend from a single male. The paucity of whole Y-chromosome sequences precluded conclusive identification of this ancestor’s age, geographic origin and migration patterns. Here, we report the variation of 486 Y-chromosomes within the Ashkenazi and non-Ashkenazi Levite R1a clade, other Ashkenazi Jewish paternal lineages, as well as non-Levite Jewish and non-Jewish R1a samples. Cumulatively, the emerging profile is of a Middle Eastern ancestor, self-affiliating as Levite, and carrying the highly resolved R1a-Y2619 lineage, which was likely a minor haplogroup among the Hebrews. A star-like phylogeny, coalescing similarly to other Ashkenazi paternal lineages, ~1,743 ybp, suggests it to be one of the Ashkenazi paternal founders; to have expanded as part of the overall Ashkenazi demographic expansion, without special relation to the Levite affiliation; and to have subsequently spread to non-Ashkenazi Levites.
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影响因子：
56.9
作者：
Gymrek, Melissa;McGuire, Amy L.;Erlich, Yaniv
通讯作者：
Erlich, Yaniv
影响因子：
30.8
作者：
Helgason, Agnar;Einarsson, Axel W.;Stefansson, Kari
通讯作者：
Stefansson, Kari
影响因子：
7
作者：
Karmin M;Saag L;Vicente M;Wilson Sayres MA;Järve M;Talas UG;Rootsi S;Ilumäe AM;Mägi R;Mitt M;Pagani L;Puurand T;Faltyskova Z;Clemente F;Cardona A;Metspalu E;Sahakyan H;Yunusbayev B;Hudjashov G;DeGiorgio M;Loogväli EL;Eichstaedt C;Eelmets M;Chaubey G;Tambets K;Litvinov S;Mormina M;Xue Y;Ayub Q;Zoraqi G;Korneliussen TS;Akhatova F;Lachance J;Tishkoff S;Momynaliev K;Ricaut FX;Kusuma P;Razafindrazaka H;Pierron D;Cox MP;Sultana GN;Willerslev R;Muller C;Westaway M;Lambert D;Skaro V;Kovačevic L;Turdikulova S;Dalimova D;Khusainova R;Trofimova N;Akhmetova V;Khidiyatova I;Lichman DV;Isakova J;Pocheshkhova E;Sabitov Z;Barashkov NA;Nymadawa P;Mihailov E;Seng JW;Evseeva I;Migliano AB;Abdullah S;Andriadze G;Primorac D;Atramentova L;Utevska O;Yepiskoposyan L;Marjanovic D;Kushniarevich A;Behar DM;Gilissen C;Vissers L;Veltman JA;Balanovska E;Derenko M;Malyarchuk B;Metspalu A;Fedorova S;Eriksson A;Manica A;Mendez FL;Karafet TM;Veeramah KR;Bradman N;Hammer MF;Osipova LP;Balanovsky O;Khusnutdinova EK;Johnsen K;Remm M;Thomas MG;Tyler-Smith C;Underhill PA;Willerslev E;Nielsen R;Metspalu M;Villems R;Kivisild T
通讯作者：
Kivisild T
影响因子：
9.8
作者：
Atzmon, Gil;Hao, Li;Ostrer, Harry
通讯作者：
Ostrer, Harry
DOI：
10.1093/bioinformatics/btp352
发表时间：
2009-08-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Li H;Handsaker B;Wysoker A;Fennell T;Ruan J;Homer N;Marth G;Abecasis G;Durbin R;1000 Genome Project Data Processing Subgroup
通讯作者：
1000 Genome Project Data Processing Subgroup