Better skeletal microstructure confers greater mechanical advantages in Chinese-American women versus white women.
Better skeletal microstructure confers greater mechanical advantages in Chinese-American women versus white women.
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DOI：
10.1002/jbmr.378
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发表时间：
2011-08
影响因子：
6.2
通讯作者：
Guo, X. Edward
中科院分区：
文献类型：
--
作者：
Liu, X. Sherry;Walker, Marcella D.;McMahon, Donald J.;Udesky, Julia;Liu, George;Bilezikian, John P.;Guo, X. Edward
关键词：
尽管面骨矿物质密度 (aBMD) 较低，但华裔美国女性的骨折率却比白人女性少。我们假设华裔美国女性更好的骨骼微观结构可以部分解释这一悖论。将个体小梁分割（ITS）（一种新颖的图像分析技术）和微有限元分析（μFEA）应用于高分辨率外周定量计算机断层扫描（HR-pQCT）图像，以确定绝经前华裔美国和白人女性的骨微结构和强度。与白人女性相比，华裔美国女性的桡骨远端和胫骨的板骨体积分数分别高出 95% 和 80%，板数密度高出 20% 和 18% (p < .001)。由于具有相似的棒状特征，美籍华人的板棒比是白色小梁骨的两倍 (p < .001)。板-杆连接密度（指示小梁网络连接的参数）在华裔美国女性中在桡骨远端和胫骨处分别高出 37% 和 29% (p < .002)。此外，华裔美国女性的小梁骨网络的方向更轴向对齐，因为与白人女性相比，桡骨远端和胫骨的轴向骨体积分数分别高出 51% 和 32% (p < .001)。根据杨氏模量评估，华裔美国人与白人组相比，小梁骨微观结构的这些显着差异转化为 55% 至 68%（远端半径，p < .001）和 29% 至 43%（远端胫骨，p < .01）的骨小梁强度增加。华裔美国女性比白人女性具有显着的微观结构优势这一观察结果可能有助于解释为什么尽管她们的骨密度较低，但她们骨折的风险却较低。
Despite lower areal bone mineral density (aBMD), Chinese-American women have fewer fractures than white women. We hypothesized that better skeletal microstructure in Chinese-American women in part could account for this paradox. Individual trabecula segmentation (ITS), a novel image-analysis technique, and micro–finite-element analysis (μFEA) were applied to high-resolution peripheral quantitative computed tomography (HR-pQCT) images to determine bone microarchitecture and strength in premenopausal Chinese-American and white women. Chinese-American women had 95% and 80% higher plate bone volume fraction at the distal radius and tibia, respectively, as well as 20% and 18% higher plate number density compared with white women (p < .001). With similar rodlike characteristics, the plate-to-rod ratio was twice as high in the Chinese-American than in white trabecular bone (p < .001). Plate-rod junction density, a parameter indicating trabecular network connections, was 37% and 29% greater at the distal radius and tibia, respectively, in Chinese-American women (p < .002). Moreover, the orientation of the trabecular bone network was more axially aligned in Chinese-American women because axial bone volume fraction was 51% and 32% higher at the distal radius and tibia, respectively, than in white women (p < .001). These striking differences in trabecular bone microstructure translated into 55% to 68% (distal radius, p < .001) and 29% to 43% (distal tibia, p < .01) greater trabecular bone strength, as assessed by Young’s moduli, in the Chinese-American versus the white group. The observation that Chinese-American women have a major microstructural advantage over white women may help to explain why their risk of fracture is lower despite their lower BMD.
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影响因子：
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作者：
Cohen, Adi;Liu, X. Sherry;Shane, Elizabeth
通讯作者：
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影响因子：
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通讯作者：
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