Trends of microneedle technology in the scientific literature, patents, clinical trials and internet activity.
Trends of microneedle technology in the scientific literature, patents, clinical trials and internet activity.
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DOI：
10.1016/j.biomaterials.2020.120491
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发表时间：
2021-01
期刊：
影响因子：
14
通讯作者：
Prausnitz MR
中科院分区：
文献类型：
--
作者：
Ingrole RSJ;Azizoglu E;Dul M;Birchall JC;Gill HS;Prausnitz MR
强大而有趣的想法，推动了新兴的微针技术-缩小标准针到微米级-已经培养了整个领域的微针研究和随后的指数增长的研究和产品开发。微针最初由来自微电子工业的微制造工具实现，现在通过多种方法以各种形式生产微针，包括实心、涂层、可溶解和中空微针。它们用于将广谱分子，包括小分子，生物分子和疫苗，以及各种形式的能量输送到皮肤，眼睛和其他组织中。针头也被开发用于诊断以及其他医疗、美容和其他应用。该综述阐明了微针技术开发不同方面的相对作用，如科学论文、专利、临床研究和互联网/社交媒体活动所示。考虑到>1000篇论文，750项专利和近80项临床试验，我们分析了微针的不同属性，例如微针的使用，微针的类型，测试环境，专利要求的类型和临床试验的阶段，以及来自不同地点和不同期刊的学术界和工业界的机构和人员正在出版，申请专利，或者研究微针的潜力。我们的结论是，在微针领域有强大的和不断增长的活动;该技术正在迅速发展，并被用于新的应用，以造福人类健康和福祉。
The powerful and intriguing idea that drives the emerging technology of microneedles—shrinking the standard needle to a micron scale—has fostered an entire field of microneedle study and subsequent exponential growth in research and product development. Originally enabled by microfabrication tools derived from the microelectronic industry, microneedles are now produced through a number of methods in a variety of forms including solid, coated, dissolvable, and hollow microneedles. They are used to deliver a broad spectrum of molecules, including small molecules, biomolecules, and vaccines, as well as various forms of energy into the skin, eye, and other tissues. Microneedles are also being exploited for use in diagnostics, as well as additional medical, cosmetic, and other applications. This review elucidates the relative roles of different aspects of microneedle technology development, as shown through scientific papers, patents, clinical studies, and internet/social media activity. Considering >1000 papers, 750 patents, and almost 80 clinical trials, we analyze different attributes of microneedles such as usage of microneedles, types of microneedles, testing environment, types of patent claims, and phases of clinical trials, as well as which institutions and people in academia and industry from different locations and in different journals are publishing, patenting, and otherwise studying the potential of microneedles. We conclude that there is robust and growing activity in the field of microneedles; the technology is rapidly developing and being used for novel applications to benefit human health and well-being.
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影响因子：
7.3
作者：
Bakos RM;Blumetti TP;Roldán-Marín R;Salerni G
通讯作者：
Salerni G
影响因子：
4
作者：
Moffatt, Kurtis;Wang, Yujing;Donnelly, Ryan F.
通讯作者：
Donnelly, Ryan F.
影响因子：
46.9
作者：
Prausnitz, Mark R.;Langer, Robert
通讯作者：
Langer, Robert
DOI：
10.3390/s17081866
发表时间：
2017-08-12
期刊：
Sensors (Basel, Switzerland)
影响因子：
--
作者：
Bruen D;Delaney C;Florea L;Diamond D
通讯作者：
Diamond D
DOI：
10.1016/j.jconrel.2017.09.016
发表时间：
2017-12-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Kim SM;Faix PH;Schnitzer JE
通讯作者：
Schnitzer JE