INERTIA: A pilot study of the impact of progressive resistance training on blood pressure control in older adults with sarcopenia.
INERTIA: A pilot study of the impact of progressive resistance training on blood pressure control in older adults with sarcopenia.
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惯性：渐进阻力训练对老年肌肉减少症患者血压控制影响的初步研究。
DOI：
10.1016/j.cct.2021.106516
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发表时间：
2021-09
影响因子：
2.2
通讯作者：
Ma J
中科院分区：
文献类型：
--
作者：
Laddu D;Kim H;Phillips SA;Ma J
骨质疏松症和高血压是非常普遍的、可预防的疾病，对老年人和医疗保健系统构成重大负担。目前，通过非药物方法预防和治疗石棺减少症中的高血压仍然有限，而且远未达到最佳效果。临床试验和机制研究提供了令人鼓舞的证据，证明渐进式阻力训练(PRT)对较年轻、高血压前期和高血压前期的老年人具有看似合理的治疗效果。PRT对血压的影响还没有在患有石棺减少的老年人身上进行经验测试。这项先导性研究旨在为一项全面的随机对照试验提供有效的大小可信区间、临床试验和干预可行性数据以及程序性材料，该试验将确定PRT干预作为一种治疗策略对患有骨质疏松症的老年人血压控制的有效性。参与者(N=90)将被随机接受运动教育材料或PRT干预，该干预包括在12周内监督24次运动。后续评估将在12周和一年后进行。主要结果是分别分析的收缩压和舒张压。将在基线和12周时探索将肌肉(血流、力量、功能)与血压变化联系起来的微血管机制。这项研究将为PRT作为一种非药物降压策略的治疗效果提供新的证据。所获得的见解也可能为肌肉力量作为血压控制的新目标的潜在作用提供信息，以及未来与高危老年人肌肉强化相关的运动处方指南。
Sarcopenia, and high blood pressure are highly prevalent, preventable conditions that pose significant burden for older adults and on the healthcare system. Current prevention and treatment of high blood pressure in sarcopenia, by non-pharmacological approaches remain limited and are far from optimal. Clinical trials and mechanistic studies provide encouraging evidence of a plausible therapeutic effect of progressive resistance training (PRT) on blood pressure in younger, and pre-hypertensive and hypertensive older adults. The impact of PRT on blood pressure has not been empirically tested in older adults with sarcopenia. This pilot study aims to provide effect size confidence intervals, clinical trial and intervention feasibility data, and procedural materials for a full-scale randomized controlled trial that will determine the efficacy of PRT intervention as a therapeutic strategy for blood pressure control in older adults with sarcopenia. Participants (N= 90) will be randomized to receive exercise educational materials or the PRT intervention consisting of 24 supervised exercise sessions over 12-weeks. Follow-up assessments will occur at 12-weeks and one-year later. The primary outcome is systolic blood pressure and diastolic blood pressure, analyzed separately. Microvascular mechanisms linking muscle (perfusion, strength, function) to changes in blood pressure will be explored at baseline and 12-weeks. This study will provide new evidence for the therapeutic effect of PRT as a non-pharmacological strategy for improving blood pressure. Insights gained may also inform of the potential role of muscle strength as a novel target for blood pressure control, and future exercise prescription guidelines related to muscle strengthening in high-risk older adults.
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影响因子：
5.4
作者：
Cornelissen VA;Smart NA
通讯作者：
Smart NA
DOI：
10.1093/gerona/52a.5.m275
发表时间：
1997-09-01
影响因子：
5.1
作者：
Ferrucci, L;Guralnik, JM;Fried, LP
通讯作者：
Fried, LP
DOI：
10.1249/00005768-198205000-00012
发表时间：
1982-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
BORG, GAV
通讯作者：
BORG, GAV
影响因子：
24
作者：
Artero, Enrique G.;Lee, Duck-chul;Ruiz, Jonatan R.;Sui, Xuemei;Ortega, Francisco B.;Church, Timothy S.;Lavie, Carl J.;Castillo, Manuel J.;Blair, Steven N.
通讯作者：
Blair, Steven N.
影响因子：
4.7
作者：
Coelho Júnior HJ;Aguiar Sda S;Gonçalves Ide O;Sampaio RA;Uchida MC;Moraes MR;Asano RY
通讯作者：
Asano RY