A prospective study of muscular strength and all-cause mortality in men with hypertension.
A prospective study of muscular strength and all-cause mortality in men with hypertension.
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DOI：
10.1016/j.jacc.2010.12.025
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发表时间：
2011-05-03
影响因子：
24
通讯作者：
Blair, Steven N.
中科院分区：
文献类型：
--
作者：
Artero, Enrique G.;Lee, Duck-chul;Ruiz, Jonatan R.;Sui, Xuemei;Ortega, Francisco B.;Church, Timothy S.;Lavie, Carl J.;Castillo, Manuel J.;Blair, Steven N.
评估肌肉力量对男性高血压患者死亡率的影响。在健康男性中，肌肉力量与死亡率呈负相关，但这种相关性在患有高血压的男性中尚未得到检验。从1980年到2003年，我们跟踪调查了参加有氧运动中心纵向研究的1506名年龄在≥40岁的高血压男性。参与者在基线时接受了广泛的体检。肌肉力量通过结合腿部和仰卧起坐的一个重复最大值(1-RM)测量和通过跑步机上的最大运动试验评估的心肺适能(CRF)来量化。在平均18.3年的随访期间，发生了183例死亡。年龄调整死亡率为81.8、65.5和52.0(线性趋势P<；0.05)。多变量Cox回归风险比分别为1.0(参考)、0.81(95%可信区间，0.57~1.14)和0.59(0.40~0.86)。在进一步调整CRF后，那些肌肉力量处于上三分之一的参与者的死亡风险仍然较低(0.66；0.45至0.98)。在肌力和CRF联合分析中，同时处于肌力上三分之一和高体能组的男性在所有组合组中死亡风险最低(0.49；0.30~0.82)，以肌力下三分之一和低体能组男性为参照。高水平的肌肉力量似乎可以保护高血压男性免受各种原因造成的死亡，这是CRF提供的好处之外的。
To assess the impact of muscular strength on mortality in men with hypertension. Muscular strength is inversely associated with mortality in healthy men, but this association has not been examined in men with hypertension. We followed 1506 hypertensive men aged ≥ 40 years enrolled in the Aerobics Center Longitudinal Study from 1980 to 2003. Participants received an extensive medical examination at baseline. Muscular strength was quantified by combining one repetition maximum (1-RM) measures for leg and bench press, and cardiorespiratory fitness (CRF) assessed by maximum exercise test on a treadmill. During an average follow-up of 18.3 years, 183 deaths occurred. Age adjusted death rates per 10 000 man-years across incremental thirds of muscular strength were 81.8, 65.5 and 52.0 (P<0.05 for linear trend). Multivariable Cox regression hazard ratios were 1.0 (reference), 0.81 (95% confidence interval, 0.57 to 1.14), and 0.59 (0.40 to 0.86) across incremental thirds of muscular strength. After further adjustment for CRF, those participants in the upper third of muscular strength still had a lower risk of death (0.66; 0.45 to 0.98). In the muscular strength and CRF combined analysis, men simultaneously in the upper third of muscular strength and high fitness group had the lowest mortality risk among all combination groups (0.49; 0.30 to 0.82), with men in the lower third of muscular strength and low fitness group as reference. High levels of muscular strength appear to protect hypertensive men against all-cause mortality, and this is in addition to the benefit provided by CRF.
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DOI：
10.1097/00005768-200205000-00002
发表时间：
2002-05-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Katzmarzyk, PT;Craig, CL
通讯作者：
Craig, CL
影响因子：
4.8
作者：
POLLOCK, ML;BOHANNON, RL;LINNERUD, AC
通讯作者：
LINNERUD, AC
影响因子：
8.3
作者：
Kelley, GA;Kelley, KS
通讯作者：
Kelley, KS
影响因子：
4.4
作者：
BLAIR, SN;KOHL, HW;GIBBONS, LW
通讯作者：
GIBBONS, LW
DOI：
10.1093/gerona/61.1.72
发表时间：
2006-01-01
影响因子：
5.1
作者：
Newman, AB;Kupelian, V;Harris, TB
通讯作者：
Harris, TB