The role of prognostic nutritional index for clinical outcomes of gastric cancer after total gastrectomy.
The role of prognostic nutritional index for clinical outcomes of gastric cancer after total gastrectomy.
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DOI：
10.1038/s41598-020-74525-8
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发表时间：
2020-10-15
影响因子：
4.6
通讯作者：
Shikai W
中科院分区：
文献类型：
--
作者：
Xishan Z;Ye Z;Feiyan M;Liang X;Shikai W
本文旨在评价胃癌患者营养微环境与临床病理信息的关系，探讨营养指标对胃癌全胃切除术患者的预后价值。我们回顾性收集2005年1月1日至2015年12月30日在我院行全胃切除术的245例胃癌患者的临床资料。根据预后营养指数（PNI）水平分为低PNI组（< 43）和高PNI组（≥43）。统计学分析PNI与无病生存期（DFS）和总生存期（OS）的关系。单因素分析显示，TNM分期（p = 0.025）、患者年龄（p = 0.042）、淋巴结转移（p = 0.028）、肿瘤分化（p = 0.037）和低PNI （p = 0.033）与预后不良密切相关。在多变量分析中，发现TNM分期（p = 0.027）和低PNI （p = 0.041）与生存率差独立相关。此外，当年龄被视为分层因素时，单因素分析表明，低PNI与非老年（< 65）患者较短的DFS （p = 0.022）和老年（≥65）患者较短的DFS （p = 0.036）和OS （p = 0.047）相关。低预后营养指数是胃癌生存不良的独立危险因素，它代表了营养微环境。术前预后营养指数较低的患者术后应密切观察，防止近期发生术后并发症。
The purpose of this article is to evaluate the relationship between the nutrition-based microenvironment and clinicopathological information for gastric cancer patients and to investigate the prognostic value of nutrition index for gastric cancer patients undergoing total gastrectomy. We retrospectively collected clinical information of 245 gastric cancer patients who underwent total gastrectomy in our hospital between January 1st 2005 and December 30th 2015. According to the prognostic nutritional index (PNI) level, they were divided into low PNI (< 43) group and high PNI (≥ 43) group. The relationship between PNI and the disease-free survival (DFS) and overall survival (OS) were analyzed by statistical analysis. Univariate analyses demonstrated that TNM stage (p = 0.025), patients age (p = 0.042), lymph node metastasis (p = 0.028), tumor differentiation (p = 0.037) and a low PNI (p = 0.033) were closely correlated with a poor prognosis. In multivariate analysis, TNM stage (p = 0.027) and a low PNI (p = 0.041) were found to be independently associated with poor survival. Additionally, when age was considered as a stratified factor, univariate analyses demonstrated that low PNI correlated with shorter DFS in non-elderly (< 65) patients (p = 0.022) and shorter DFS (p = 0.036) and OS (p = 0.047) in elderly (≥ 65) patients. The low prognostic nutritional index is an independent risk factor associated with poor gastric cancer survival which represents the nutritional microenvironment. Patients with low pre-operative prognostic nutritional index levels should be observed more closely after surgery to prevent the occurrence of post-operative complications in the near future.
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影响因子：
--
作者：
Dai, Yaqing;Fu, Xiaobin;Li, Jiancheng
通讯作者：
Li, Jiancheng
影响因子：
2.6
作者：
Mohri, Yasuhiko;Inoue, Yasuhiro;Kusunoki, Masato
通讯作者：
Kusunoki, Masato
影响因子：
3.8
作者：
Feng Z;Wen H;Ju X;Bi R;Chen X;Yang W;Wu X
通讯作者：
Wu X
DOI：
10.1053/ejso.2002.1257
发表时间：
2002-06-01
期刊：
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY
影响因子：
--
作者：
Nozoe, T;Kimura, Y;Sugimachi, K
通讯作者：
Sugimachi, K
影响因子：
3.7
作者：
Mori S;Usami N;Fukumoto K;Mizuno T;Kuroda H;Sakakura N;Yokoi K;Sakao Y
通讯作者：
Sakao Y