Factors associated with odour identification in older Indonesian and white Australian adults.
Factors associated with odour identification in older Indonesian and white Australian adults.
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DOI：
10.1007/s40520-019-01419-9
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发表时间：
2020-03
影响因子：
4
通讯作者：
For Cohort Studies of Memory in an International Consortium (COSMIC)
中科院分区：
文献类型：
--
作者：
Turana Y;Lipnicki DM;Handajani YS;Sani TP;Widayanti JR;Suswanti I;Kochan NA;Brodaty H;Sachdev PS;For Cohort Studies of Memory in an International Consortium (COSMIC)
在老年人中，嗅觉功能障碍与认知障碍、生活质量降低和死亡率增加有关。虽然年龄是嗅觉功能障碍的一个危险因素，但其他危险因素还不太清楚，并且可能在种族-地区群体之间存在差异。本研究调查了气味识别（OI）和各种危险因素之间的关联，以及认知和语言能力，在两个不同的民族地区老年人群体中是不同的还是相似的。这项横断面研究使用了来自两个队列的数据：470名澳大利亚人（年龄67.4 ± 7.4岁）和819名白色澳大利亚人（年龄78.7 ± 4.8岁）。单变量和多变量分析探讨了OI测试分数是否与年龄、性别、教育、胆固醇水平、载脂蛋白E ε4状态、吸烟、糖尿病、高血压和抑郁量表分数相关，或与简易精神状态检查（MMSE）和语言测试表现相关。单变量分析确定了一些与澳大利亚人和白色澳大利亚人的OI得分相关的因素，包括年龄较大和吸烟得分较低，MMSE和语言测试表现得分较高。多变量分析得出了两个民族区域组中不同的和相互排斥的关联模式，在澳大利亚人中，语言测试分数与较高的OI分数显著相关，而在白色澳大利亚人中，年龄、男性、吸烟、糖尿病和较高的抑郁量表分数与较低的OI分数显著相关。在试图充分理解OI与痴呆和死亡率等负面结果之间的关联时，可能需要考虑种族-地区差异，并且可能需要针对特定的种族-地区群体进行嗅觉功能障碍干预。然而，队列之间的平均年龄差异是本研究的局限性，未来的研究应旨在比较具有相似年龄分布的人群。
Among older adults, olfactory dysfunction is associated with cognitive impairment, lower quality of life, and increased mortality. While age is a risk factor for olfactory dysfunction, other risk factors are less well understood, and may vary between ethno-regional groups. This study investigated how associations between odour identification (OI) and various risk factors, as well as cognition and language ability, differed or were similar in two distinct ethno-regional groups of older adults. This cross-sectional study used data from two cohorts: 470 Indonesians (aged 67.4 ± 7.4 years) and 819 white Australians (aged 78.7 ± 4.8 years). Univariate and multivariate analyses explored whether OI test scores were associated with age, sex, education, cholesterol levels, apolipoprotein E ε4 status, smoking, diabetes, hypertension and depression scale scores, or with Mini-Mental State Examination (MMSE) and language test performance. Univariate analyses identified some factors associated with OI scores in both Indonesians and white Australians, including older age and smoking with lower scores, and MMSE and language test performance with higher scores. Multivariate analyses yielded different and mutually exclusive patterns of associations in the two ethno-regional groups, with language test scores significantly associated with higher OI scores in Indonesians, and age, being male, smoking, having diabetes and higher depression scale scores significantly associated with lower OI scores in white Australians. Ethno-regional differences may need consideration in the attempt to fully understand associations between OI and negative outcomes like dementia and mortality, and interventions for olfactory dysfunction might need to be tailored to specific ethno-regional groups. However, the difference in mean age between cohorts is a limitation of this study, and future studies should aim to compare populations with similar age distributions.
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影响因子：
4.6
作者：
Kass MD;Czarnecki LA;Moberly AH;McGann JP
通讯作者：
McGann JP
在处于危险中的老年人中，气味鉴定为临床前广告的生物标志物。
影响因子：
9.9
作者：
Lafaille-Magnan ME;Poirier J;Etienne P;Tremblay-Mercier J;Frenette J;Rosa-Neto P;Breitner JCS;PREVENT-AD Research Group
通讯作者：
PREVENT-AD Research Group
影响因子：
2.8
作者：
Gouveri, E.;Katotomichelakis, M.;Papanas, N.
通讯作者：
Papanas, N.
DOI：
10.1093/gerona/glx081
发表时间：
2017-08-01
影响因子：
5.1
作者：
Dong, Jing;Pinto, Jayant M.;Chen, Honglei
通讯作者：
Chen, Honglei
影响因子：
6.3
作者：
Ekstrom, Ingrid;Sjolund, Sara;Olofsson, Jonas K.
通讯作者：
Olofsson, Jonas K.