Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation.
Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation.
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DOI：
10.1016/j.immuni.2011.10.015
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发表时间：
2011-12-23
期刊：
影响因子：
32.4
通讯作者：
Kuchroo VK
中科院分区：
文献类型：
--
作者：
Peters A;Pitcher LA;Sullivan JM;Mitsdoerffer M;Acton SE;Franz B;Wucherpfennig K;Turley S;Carroll MC;Sobel RA;Bettelli E;Kuchroo VK
异位淋巴滤泡是慢性自身免疫性炎症疾病的标志，如多发性硬化症（MS）、类风湿性关节炎、Sjögren综合征和重症肌无力。然而，诱导其发育的效应细胞和机制尚不清楚。本研究表明，在MS动物模型——实验性自身免疫性脑脊髓炎（EAE）中，Th17细胞特异性诱导中枢神经系统（CNS）的异位淋巴滤泡。异位淋巴滤泡的发育部分依赖于细胞因子白介素17 （IL-17）和细胞表面分子Podoplanin (Pdp)，后者在Th17细胞上表达，但不影响其他效应T细胞亚群。Pdp对继发性淋巴结构的发展也至关重要：Pdp缺陷小鼠缺乏周围淋巴结，在形成正常淋巴滤泡和脾脏和淋巴结残余生发中心方面存在缺陷。因此，Th17细胞具有独特的诱导组织炎症的能力，其特征是靶器官内的异位淋巴滤泡。
Ectopic lymphoid follicles are hallmarks of chronic autoimmune inflammatory diseases such as multiple sclerosis (MS), rheumatoid arthritis, Sjögren’s syndrome, and myasthenia gravis. However, the effector cells and mechanisms that induce their development are unknown. Here we showed that in experimental autoimmune encephalomyelitis (EAE), the animal model of MS, Th17 cells specifically induced ectopic lymphoid follicles in the central nervous system (CNS). Development of ectopic lymphoid follicles was partly dependent on the cytokine interleukin 17 (IL-17) and on the cell surface molecule Podoplanin (Pdp), which was expressed on Th17 cells, but not on other effector T cell subsets. Pdp was also crucial for the development of secondary lymphoid structures: Pdp-deficient mice lacked peripheral lymph nodes and had a defect in forming normal lymphoid follicles and germinal centers in spleen and lymph node remnants. Thus, Th17 cells are uniquely endowed to induce tissue inflammation, characterized by ectopic lymphoid follicles within the target organ.
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DOI：
10.4049/jimmunol.0802808
发表时间：
2009-04-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kerrigan AM;Dennehy KM;Mourão-Sá D;Faro-Trindade I;Willment JA;Taylor PR;Eble JA;Reis e Sousa C;Brown GD
通讯作者：
Brown GD
影响因子：
6
作者：
Hirakawa, S;Hong, YK;Detmar, M
通讯作者：
Detmar, M
影响因子：
30.5
作者：
Doreau, Agnes;Belot, Alexandre;Bonnefoy-Berard, Nathalie
通讯作者：
Bonnefoy-Berard, Nathalie
影响因子：
3.3
作者：
Columba-Cabezas, Sandra;Griguoli, Marilena;Aloisi, Francesca
通讯作者：
Aloisi, Francesca
影响因子：
2.7
作者：
Ramirez, MI;Millien, G;Williams, MC
通讯作者：
Williams, MC