Global burden of deaths from Epstein-Barr virus attributable malignancies 1990-2010.
Global burden of deaths from Epstein-Barr virus attributable malignancies 1990-2010.
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DOI：
10.1186/1750-9378-9-38
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发表时间：
2014
影响因子：
3.7
通讯作者：
Hashim MJ
中科院分区：
文献类型：
--
作者：
Khan G;Hashim MJ
EB 病毒 (EBV) 是一种致癌病毒，与许多淋巴和上皮来源的人类恶性肿瘤的发病机制有关。因此，针对 EB 病毒所致恶性肿瘤的全球负担进行全面且最新的分析具有重大意义。根据已发表的研究，我们考虑了年龄、性别和地域差异，估计了 EB 病毒导致的伯基特淋巴瘤 (BL)、霍奇金淋巴瘤 (HL)、鼻咽癌 (NPC)、胃癌 (GC) 和移植后淋巴组织增生性疾病 (PTLD) 的比例。然后将这一比例归入 2010 年全球疾病负担数据集，以确定 1990 年至 2010 年间 20 个不同年龄组和 21 个世界区域的男性和女性中每种 EBV 所致恶性肿瘤的全球负担。分析表明，2010 年所有 EBV 所致恶性肿瘤造成的全球死亡负担合计为 142,979 人，占所有癌症的 1.8%死亡。这一负担在 20 年间增加了 14.6%。所有 5 种 EBV 所致恶性肿瘤在所有地理区域的男性中均更为常见（比例为 2.6:1）。胃癌和鼻咽癌占所有 EB 病毒所致癌症死亡的 92%。近 50% EB 病毒引起的恶性肿瘤发生在东亚。该地区的 NPC 和 GC 的年龄标准化死亡率也最高。 2010 年，大约有 143,000 人死于 EB 病毒相关恶性肿瘤。这个数字可能被低估，因为一些不太常见的 EBV 相关恶性肿瘤尚未包括在内。此外，全球人口和预期寿命的增长将进一步增加 EB 病毒相关癌症死亡的总体负担。开发合适的疫苗可能会对减轻这种负担产生重大影响。本文的在线版本 (doi:10.1186/1750-9378-9-38) 包含补充材料，可供授权用户使用。
Epstein-Barr virus (EBV) is an oncogenic virus implicated in the pathogenesis of a number of human malignancies of both lymphoid and epithelial origin. Thus, a comprehensive and up-to-date analysis focused on the global burden of EBV-attributable malignancies is of significant interest. Based on published studies, we estimated the proportion of Burkitt’s lymphoma (BL), Hodgkin’s lymphoma (HL), nasopharyngeal carcinoma NPC), gastric carcinoma (GC) and post-transplant lymphoproliferative disease (PTLD) attributable to EBV, taking into consideration age, sex and geographical variations. This proportion was then imputed into the Global Burden of Disease 2010 dataset to determine the global burden of each EBV-attributable malignancy in males and females in 20 different age groups and 21 world regions from 1990 to 2010. The analysis showed that the combined global burden of deaths in 2010 from all EBV-attributable malignancies was 142,979, representing 1.8% of all cancer deaths. This burden has increased by 14.6% over a period of 20 years. All 5 EBV-attributable malignancies were more common in males in all geographical regions (ratio of 2.6:1). Gastric cancer and NPC accounted for 92% of all EBV-attributable cancer deaths. Almost 50% of EBV-attributed malignancies occurred in East Asia. This region also had the highest age-standardized death rates for both NPC and GC. Approximately 143,000 deaths in 2010 were attributed to EBV-associated malignancies. This figure is likely to be an underestimate since some of the less prevalent EBV-associated malignancies have not been included. Moreover, the global increase in population and life-expectancy will further increase the overall burden of EBV-associated cancer deaths. Development of a suitable vaccine could have a substantial impact on reducing this burden. The online version of this article (doi:10.1186/1750-9378-9-38) contains supplementary material, which is available to authorized users.
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影响因子：
9
作者：
Jain, A;Nalesnik, M;Fung, J
通讯作者：
Fung, J
影响因子：
8.4
作者：
Boerma, EG;van Imhoff, GW;Kluin-Nelemans, JC
通讯作者：
Kluin-Nelemans, JC
影响因子：
5.4
作者：
Chapman, Jeremy R.;Webster, Angela C.;Wong, Germaine
通讯作者：
Wong, Germaine
影响因子：
17.1
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Cohen JI;Fauci AS;Varmus H;Nabel GJ
通讯作者：
Nabel GJ
影响因子：
50.5
作者：
Flavell, KJ;Billingham, LJ;Murray, PG
通讯作者：
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