Stem cell therapy for retinal diseases: update.
Stem cell therapy for retinal diseases: update.
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DOI：
10.1186/scrt91
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发表时间：
2011-12-29
影响因子：
7.5
通讯作者：
Siqueira RC
中科院分区：
文献类型：
--
作者：
Siqueira RC
不同的干细胞类型已经从胚胎中建立起来，并在胎儿组织和脐带血中以及在许多成年哺乳动物组织和器官（如骨髓、大脑、皮肤、眼睛、心脏、肾脏、肺、胃肠道、胰腺、肝脏、乳房、卵巢和前列腺）的特定龛中被鉴定出来。所有干细胞都是未分化的细胞，表现出无限的自我更新，可以产生多种细胞系或更有限的祖细胞群，可以通过补充细胞或损伤后的组织再生来促进组织稳态。近年来再生医学的显著进展表明，干细胞在眼科疾病治疗中的应用前景广阔。玻璃体内骨髓源性干细胞的实验和人体研究已经开始。本文综述了干细胞在视网膜疾病细胞治疗中的最新进展和潜在来源。
Distinct stem cell types have been established from embryos and identified in the fetal tissues and umbilical cord blood as well as in specific niches in many adult mammalian tissues and organs such as bone marrow, brain, skin, eyes, heart, kidneys, lungs, gastrointestinal tract, pancreas, liver, breast, ovaries, and prostate. All stem cells are undifferentiated cells that exhibit unlimited self-renewal and can generate multiple cell lineages or more restricted progenitor populations that can contribute to tissue homeostasis by replenishing the cells or to tissue regeneration after injury. The remarkable progress of regenerative medicine in the last few years indicates promise for the use of stem cells in the treatment of ophthalmic disorders. Experimental and human studies with intravitreal bone marrow-derived stem cells have begun. This paper reviews recent advances and potential sources of stem cells for cell therapy in retinal diseases.
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