Recent advances in diverse nanosystems for nitric oxide delivery in cancer therapy.
Recent advances in diverse nanosystems for nitric oxide delivery in cancer therapy.
复制标题
癌症治疗中一氧化氮输送的不同纳米系统的最新进展。
DOI：
10.1016/j.apsb.2022.11.016
复制
发表时间：
2023-04
影响因子：
14.5
通讯作者：
Xiao, Yanyu
中科院分区：
文献类型：
--
作者：
Gao, Dan;Asghar, Sajid;Hu, Rongfeng;Chen, Su;Niu, Ruixin;Liu, Jia;Chen, Zhipeng;Xiao, Yanyu
关键词：
气体疗法已被证明是一种有前途和有利的治疗癌症的选择。研究表明，一氧化氮（NO）是最小的结构重要的气体分子之一，具有很大的抑制癌症的潜力。然而，它的使用存在争议和担忧，因为它根据其在肿瘤中的水平表现出相反的生理作用。因此，NO的抗癌机制是肿瘤治疗的关键，合理设计NO给药系统是NO生物医学应用成功的关键。本文综述了NO的内源性产生、生理作用机制、NO在肿瘤治疗中的应用以及NO供体的纳米递送系统。此外，它简要地回顾了从不同的纳米粒子提供NO的挑战和与其组合治疗策略相关的问题。概括了各种NO递送平台的优点和挑战，以便可能转化为临床应用。NO在癌症治疗中的作用，用于NO供体单独递送以及与其他方式组合的纳米平台，以及挑战。
Gas therapy has been proven to be a promising and advantageous treatment option for cancers. Studies have shown that nitric oxide (NO) is one of the smallest structurally significant gas molecules with great potential to suppress cancer. However, there is controversy and concern about its use as it exhibits the opposite physiological effects based on its levels in the tumor. Therefore, the anti-cancer mechanism of NO is the key to cancer treatment, and rationally designed NO delivery systems are crucial to the success of NO biomedical applications. This review summarizes the endogenous production of NO, its physiological mechanisms of action, the application of NO in cancer treatment, and nano-delivery systems for delivering NO donors. Moreover, it briefly reviews challenges in delivering NO from different nanoparticles and the issues associated with its combination treatment strategies. The advantages and challenges of various NO delivery platforms are recapitulated for possible transformation into clinical applications. Roles of NO in cancer treatment, nanoplatforms for NO donors’ delivery alone as well as in combination with other modalities, and the challenges.
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影响因子：
5.6
作者：
Bonfili L;Gong C;Lombardi F;Cifone MG;Eleuteri AM
通讯作者：
Eleuteri AM
影响因子：
64.8
作者：
Chen, Chun-An;Wang, Tse-Yao;Varadharaj, Saradhadevi;Reyes, Levy A.;Hemann, Craig;Talukder, M. A. Hassan;Chen, Yeong-Renn;Druhan, Lawrence J.;Zweier, Jay L.
通讯作者：
Zweier, Jay L.
用于癌症治疗诊断的氧化还原响应纳米颗粒封装黑磷量子点
影响因子：
18.9
作者：
Chen H;Liu Z;Wei B;Huang J;You X;Zhang J;Yuan Z;Tang Z;Guo Z;Wu J
通讯作者：
Wu J
DOI：
10.1038/s41581-021-00429-z
发表时间：
2021-09
期刊：
Nature reviews. Nephrology
影响因子：
--
作者：
Carlström M
通讯作者：
Carlström M
影响因子：
4.6
作者：
Botteon CEA;Silva LB;Ccana-Ccapatinta GV;Silva TS;Ambrosio SR;Veneziani RCS;Bastos JK;Marcato PD
通讯作者：
Marcato PD