Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics.
Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics.
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用于癌症治疗诊断的氧化还原响应纳米颗粒封装黑磷量子点
DOI：
10.1016/j.bioactmat.2020.08.034
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发表时间：
2021-03
影响因子：
18.9
通讯作者：
Wu J
中科院分区：
文献类型：
--
作者：
Chen H;Liu Z;Wei B;Huang J;You X;Zhang J;Yuan Z;Tang Z;Guo Z;Wu J
有效的癌症治疗对癌症治疗诊断学提出了很高的要求。对于癌症诊断，光学相干断层扫描（OCT）技术（包括光热光学相干断层扫描（PT-OCT））已经被广泛研究，因为它通过环境变化（例如PT-OCT的温度变化）引起组织中光学相变的变化。在这份报告中，氧化还原响应纳米粒子封装黑磷量子点被开发为一个强大的PT-OCT剂。简言之，将黑磷量子点（BPQD）掺入基于半胱氨酸的聚（二硫酰胺）（Cys-PDSA）中以形成稳定且可生物降解的纳米剂。BPQD/Cys-PDSA纳米颗粒（NPs）的优异光热特性使其成为一种新型的高分辨率PT-OCT生物成像造影剂。该半胱氨酸-PDSA能快速响应谷胱甘肽，并在体内外有效释放BPQDs和药物。所获得的纳米粒子具有优异的近红外（NIR）光热转换效率和药物递送能力，可作为新型治疗平台，具有非常低的化疗药物剂量和副作用。聚合物和BPQD都是可降解的，表明该平台是一种罕见的完全可生物降解的PT-OCT药物。总的来说，我们的研究突出了一种可生物降解和生物相容的基于黑磷的纳米剂，用于癌症诊断和治疗。基于黑磷的纳米平台，第一个PT-OCT纳米平台可以在体外和体内完全降解。黑磷量子点和化学药物已经成功地封装到氧化还原响应纳米颗粒中。非常低剂量的PTX（如1 mg/kg，正常剂量的1/10）可以实现该平台的优异治疗性能。
Effective cancer treatment puts high demands for cancer theranostics. For cancer diagnostics, optical coherence tomography (OCT) technology (including photothermal optical coherence tomography (PT-OCT)) has been widely investigated since it induces changes in optical phase transitions in tissue through environmental changes (such as temperature change for PT-OCT). In this report, redox responsive nanoparticle encapsulating black phosphorus quantum dots was developed as a robust PT-OCT agent. Briefly, black phosphorus quantum dots (BPQDs) are incorporated into cysteine-based poly-(disulfide amide) (Cys-PDSA) to form stable and biodegradable nanoagent. The excellent photothermal feature allows BPQD/Cys-PDSA nanoparticles (NPs) as a novel contrast agent for high-resolution PT-OCT bioimaging. The Cys-PDSA can rapidly respond to glutathione and effectively release BPQDs and drugs in vitro and in vivo. And the obtained NPs exhibit excellent near-infrared (NIR) photothermal transduction efficiency and drug delivery capacity that can serve as novel therapeutic platform, with very low chemo drug dosage and side effects. Both of the polymer and BPQD are degradable, indicating this platform is a rare PT-OCT agent that is completely biodegradable. Overall, our research highlights a biodegradable and biocompatible black phosphorus-based nanoagent for both cancer diagnosis and therapy. Black phosphorus based nanoplatform, the first PT-OCT nanoplatform could be completely degraded in vitro and in vivo. Black phosphorus quantum dots and chemo drugs have been successfully encapsulated into redox responsive nanoparticles. Very low dose of PTX (such as 1 mg/kg, 1/10 of normal dose) could achieve excellent therapeutic performance for this platform.
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