T Cells Targeting SARS-CoV-2: By Infection, Vaccination, and Against Future Variants.
T Cells Targeting SARS-CoV-2: By Infection, Vaccination, and Against Future Variants.
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靶向SARS-COV-2的T细胞：通过感染，疫苗接种和对未来变体。
DOI：
10.3389/fmed.2021.793102
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发表时间：
2021
影响因子：
3.9
通讯作者：
Valkenburg SA
中科院分区：
文献类型：
--
作者：
Nguyen THO;Cohen CA;Rowntree LC;Bull MB;Hachim A;Kedzierska K;Valkenburg SA
T细胞应答是病毒免疫的关键基石，可驱动高质量的抗体应答，建立记忆以进行回忆和病毒清除。T细胞应答的无效募集在严重COVID-19的发展中起作用，并且还表现为与其他表位特异性子集和可用T细胞受体多样性相比，男性、儿童和多样性中的细胞应答减少。SARS-CoV-2特异性T细胞应答由多种疫苗形式引起，并通过先前感染增强混合免疫。表位保守性相对良好地维持，导致对于具有减弱的血清学应答的关注变体的T细胞交叉反应性。
T cell responses are a key cornerstone to viral immunity to drive high-quality antibody responses, establishing memory for recall and for viral clearance. Inefficient recruitment of T cell responses plays a role in the development of severe COVID-19 and is also represented by reduced cellular responses in men, children, and diversity compared with other epitope-specific subsets and available T cell receptor diversity. SARS-CoV-2-specific T cell responses are elicited by multiple vaccine formats and augmented by prior infection for hybrid immunity. Epitope conservation is relatively well-maintained leading to T cell crossreactivity for variants of concern that have diminished serological responses.
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影响因子：
32.4
作者：
Ferretti AP;Kula T;Wang Y;Nguyen DMV;Weinheimer A;Dunlap GS;Xu Q;Nabilsi N;Perullo CR;Cristofaro AW;Whitton HJ;Virbasius A;Olivier KJ Jr;Buckner LR;Alistar AT;Whitman ED;Bertino SA;Chattopadhyay S;MacBeath G
通讯作者：
MacBeath G
影响因子：
64.8
作者：
Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
T细胞和抗体动力学描述了介导共证疗法个体中介导长期免疫反应的SARS-COV-2肽。
影响因子：
17.1
作者：
Bilich T;Nelde A;Heitmann JS;Maringer Y;Roerden M;Bauer J;Rieth J;Wacker M;Peter A;Hörber S;Rachfalski D;Märklin M;Stevanović S;Rammensee HG;Salih HR;Walz JS
通讯作者：
Walz JS
影响因子：
5.9
作者：
Hachim A;Kavian N;Valkenburg SA
通讯作者：
Valkenburg SA
影响因子：
64.8
作者：
Alter G;Yu J;Liu J;Chandrashekar A;Borducchi EN;Tostanoski LH;McMahan K;Jacob-Dolan C;Martinez DR;Chang A;Anioke T;Lifton M;Nkolola J;Stephenson KE;Atyeo C;Shin S;Fields P;Kaplan I;Robins H;Amanat F;Krammer F;Baric RS;Le Gars M;Sadoff J;de Groot AM;Heerwegh D;Struyf F;Douoguih M;van Hoof J;Schuitemaker H;Barouch DH
通讯作者：
Barouch DH