Response Properties of Interneurons and Pyramidal Neurons in Macaque MSTd and VPS Areas During Self-Motion
Response Properties of Interneurons and Pyramidal Neurons in Macaque MSTd and VPS Areas During Self-Motion
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猕猴MSTd和VPS区中间神经元和锥体神经元在自我运动过程中的响应特性
DOI：
10.3389/fncir.2018.00105
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Aihua Chen
中科院分区：
文献类型：
--
作者：
Yingying Zhang;Shasha Li;Danqing Jiang;Aihua Chen
为了感知自我运动知觉，大脑需要整合多模态的感觉信号，如视觉、前庭和本体感觉信号。自我运动知觉非常复杂，涉及多个候选区域。以往有关被动运动过程中自我运动知觉的研究表明，部分区域对视觉（光流）和前庭刺激的不同方向均表现出选择性反应，如内侧颞上区（MSTd）的背侧细分和视觉后sylvian裂（VPS），尽管MSTd以视觉信号为主，VPS以前庭信号为主。然而，自运动知觉的相关研究均未在皮层微回路中区分出具有不同神经元性质的不同神经元类型，这限制了我们对自运动知觉局部电路的理解。在本研究中，我们根据细胞外动作电位波形和自发放电率将记录的MSTd和VPS神经元分为假定的锥体神经元和假定的中间神经元。结果表明：(1)中间神经元对其主要刺激类型（视刺激和前庭刺激）的定向调节范围明显大于锥体神经元；(2)无论是在视觉还是前庭状态下，中间神经元对MSTd和VPS区域的反应都比锥体神经元更敏感，但变异性更大；(3)在MSTd和VPS区域，中间神经元的前庭和视觉峰值定向调谐时间早于锥体神经元。基于这些发现，我们推测，在微电路中，几个相邻的具有宽方向调谐的假定中间神经元接收到较早的强但可变的信号，这些信号可能作为前馈输入来塑造目标假定锥体神经元的方向调谐，但每个中间神经元可能参与几个微电路，针对不同的输出神经元。
To perceive self-motion perception, the brain needs to integrate multi-modal sensory signals such as visual, vestibular and proprioceptive cues. Self-motion perception is very complex and involves multi candidate areas. Previous studies related to self-motion perception during passive motion have revealed that some of the areas show selective response to different directions for both visual (optic flow) and vestibular stimuli, such as the dorsal subdivision of the medial superior temporal area (MSTd) and the visual posterior sylvian fissure (VPS), although MSTd is dominated by visual signals and VPS is dominated by vestibular signals. However, none of studies related to self-motion perception have distinguished the different neuron types with distinct neuronal properties in cortical microcircuitry, which limited our understanding of the local circuits for self-motion perception. In the current study, we classified the recorded MSTd and VPS neurons into putative pyramidal neurons and putative interneurons based on the extracellular action potential waveforms and spontaneous firing rates. We found that: (1) the putative interneurons exhibited obviously broader direction tuning than putative pyramidal neurons in response to their dominant (visual for MSTd; vestibular for VPS) stimulation type; (2) either in visual or vestibular condition, the putative interneurons were more responsive but with larger variability than the putative pyramidal neurons for both MSTd and VPS areas; and (3) the timing of vestibular and visual peak directional tuning was earlier in the putative interneurons than that of the putative pyramidal neurons for both MSTd and VPS areas. Based on these findings we speculated that, within the microcircuitry, several adjacent putative interneurons with broad direction tuning receive earlier strong but variable signals, which might act feedforward input to shape the direction tuning of the target putative pyramidal neuron, but each interneuron may participate in several microcircuitries, targeting different output neurons.
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影响因子：
5.3
作者：
Merchant, Hugo;Naselaris, Thomas;Georgopoulos, Apostolos P.
通讯作者：
Georgopoulos, Apostolos P.
影响因子：
2.5
作者：
I. Yokoi;H. Komatsu
通讯作者：
I. Yokoi;H. Komatsu
DOI：
10.1523/jneurosci.1266-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Chen A;DeAngelis GC;Angelaki DE
通讯作者：
Angelaki DE
影响因子：
16.2
作者：
Mitchell, Jude F.;Sundberg, Kristy A.;Reynolds, John H.
通讯作者：
Reynolds, John H.
DOI：
10.4324/9781315807683
发表时间：
2014-01
期刊：
--
影响因子：
--
作者：
R. Warren;A. Wertheim
通讯作者：
R. Warren;A. Wertheim