On-Demand Fully Enclosed Superhydrophobic-Optofluidic Devices Enabled by Microstereolithography.
On-Demand Fully Enclosed Superhydrophobic-Optofluidic Devices Enabled by Microstereolithography.
复制标题
按需通过微骨术启用了完全封闭的超疏水性 - 嗜optofluidic设备。
DOI：
10.1021/acs.langmuir.2c01658
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发表时间：
2022-08-30
期刊：
影响因子：
3.9
通讯作者：
Du, Ke
中科院分区：
文献类型：
--
作者：
Chang, Yu;Bao, Mengdi;Waitkus, Jacob;Cai, Haogang;Du, Ke
超疏水表面光流控技术以其低光损耗、低功耗等独特优势被引入生物传感器和非传统光学领域。然而，这些平台大多是平面状的微结构和纳米结构，这可能会导致键合问题，并导致显著的波导损耗。在这里，我们介绍了一种完全封闭的基于超疏水的光流体系统，该系统由一步微立体光刻程序实现。研究了各种特征尺寸为100μm的微结构包层设计，其中T型悬垂设计具有最低的光学损耗，与激发波长无关。令人惊讶的是，超疏水基光流体的光学损耗不仅取决于固体/水/空气界面的固体面积分数，而且还取决于截面形状和有效包覆层的组成。我们表明，这个全封闭的光流控系统可以用于CRISPR标记的量子点定量，用于体外和体内CRISPR治疗。
Superhydrophobic surface-based optofluidics have been introduced to biosensors and unconventional optics with unique advantages, such as low light loss and power consumption. However, most of these platforms were made with planar-like microstructures and nanostructures, which may cause bonding issues and result in significant waveguide loss. Here, we introduce a fully enclosed superhydrophobic-based optofluidics system, enabled by a one-step micro-stereolithography procedure. Various micro structured cladding designs with a feature size down to 100 μm were studied and a “T-type” overhang design exhibits the lowest optical loss, regardless of the excitation wavelength. Surprisingly, the optical loss of superhydrophobic-based optofluidics is not solely decided by the solid area fraction at the solid/water/air interface, but also the cross-section shape and the effective cladding layer composition. We show that this fully enclosed optofluidic system can be used for CRISPR-labeled quantum dot quantification, intended for in vitro and in vivo CRISPR therapeutics.
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DOI：
10.1109/lpt.2009.2022276
发表时间：
2009-08-01
期刊：
IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society
影响因子：
--
作者：
Cho SH;Godin J;Lo YH
通讯作者：
Lo YH
影响因子：
3.1
作者：
Morhart, Tyler A.;Read, Stuart T.;Burgess, Ian J.
通讯作者：
Burgess, Ian J.
影响因子：
12.4
作者：
Guo, Yue;Chen, Chuanrui;Peng, Huisheng
通讯作者：
Peng, Huisheng
影响因子：
30.5
作者：
Lim K;Kim TH;Trzeciak A;Amitrano AM;Reilly EC;Prizant H;Fowell DJ;Topham DJ;Kim M
通讯作者：
Kim M
影响因子：
3.4
作者：
Du K;Jiang Y;Liu Y;Wathuthanthri I;Choi CH
通讯作者：
Choi CH