Effects of Diazepam on Reaction Times to Stop and Go.
Effects of Diazepam on Reaction Times to Stop and Go.
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DOI：
10.3389/fnhum.2020.567177
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发表时间：
2020
影响因子：
2.9
通讯作者：
Kumar H
中科院分区：
文献类型：
--
作者：
Sarkar S;Choudhury S;Islam N;Chowdhury MSJH;Chowdhury MTI;Baker MR;Baker SN;Kumar H
导语：响应外部提示而停止动作执行的能力需要完整的执行功能。精神药物对运动抑制的影响在很大程度上是未知的。运动停止可以通过停止信号反应时间(SSRT)来估计。在最近的一篇文章中，我们验证了一种改进的SSRT度量(最佳组合SSRT，ocSSRT)。在这里，我们探索了增强GABAA受体传递的安定是如何影响ocSSRT的。方法：9名健康受试者随机接受安慰剂、5 mg和10 mg剂量的安定治疗。每个参与者在不同的日子分别接受剂量的药物和安慰剂的口服，并进行充分的洗涤。通过一个包含绿色(GO)和红色(STOP)发光二极管的电池供电的盒子，通过一个停止信号任务来估计ocSSRT和简单反应时间(RT)。该任务在给药前和给药后1h进行。结果：安定10 mg后OSSRT的平均变化(+27ms)显著高于安慰剂组(−1ms；p=0.012)。相比之下，简单反应时间的平均变化在所有三个剂量组中保持相似(p=0.419)。结论：我们的结果证实，成人单次治疗性剂量的安定可以改变药物幼稚的健康人的运动抑制。安定对ocSSRT的选择性作用而不是简单的RT，提示GABA能神经元可能在运动停止中起关键作用。
Introduction: The ability to stop the execution of a movement in response to an external cue requires intact executive function. The effect of psychotropic drugs on movement inhibition is largely unknown. Movement stopping can be estimated by the Stop Signal Reaction Time (SSRT). In a recent publication, we validated an improved measure of SSRT (optimum combination SSRT, ocSSRT). Here we explored how diazepam, which enhances transmission at GABAA receptors, affects ocSSRT. Methods: Nine healthy individuals were randomized to receive placebo, 5 mg or 10 mg doses of diazepam. Each participant received both the dosage of drug and placebo orally on separate days with adequate washout. The ocSSRT and simple reaction time (RT) were estimated through a stop-signal task delivered via a battery-operated box incorporating green (Go) and red (Stop) light-emitting diodes. The task was performed just before and 1 h after dosing. Result: The mean change in ocSSRT after 10 mg diazepam was significantly higher (+27 ms) than for placebo (−1 ms; p = 0.012). By contrast, the mean change in simple response time remained comparable in all three dosing groups (p = 0.419). Conclusion: Our results confirm that a single therapeutic adult dose of diazepam can alter motor inhibition in drug naïve healthy individuals. The selective effect of diazepam on ocSSRT but not simple RT suggests that GABAergic neurons may play a critical role in movement-stopping.
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