Migraine-Associated Common Genetic Variants Confer Greater Risk of Posterior vs. Anterior Circulation Ischemic Stroke☆.
Migraine-Associated Common Genetic Variants Confer Greater Risk of Posterior vs. Anterior Circulation Ischemic Stroke☆.
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DOI：
10.1016/j.jstrokecerebrovasdis.2022.106546
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发表时间：
2022-08
影响因子：
2.5
通讯作者：
Lindgren, A.
中科院分区：
文献类型：
--
作者：
Frid, P.;Xu, H.;Mitchell, B. D.;Drake, M.;Wasselius, J.;Gaynor, B.;Ryan, K.;Giese, A. K.;Schirmer, M.;Donahue, K. L.;Irie, R.;Bouts, M. J. R. J.;McIntosh, E. C.;Mocking, S. J. T.;Dalca, A. V.;Giralt-Steinhauer, E.;Holmegaard, L.;Jood, K.;Roquer, J.;Cole, J. W.;McArdle, P. F.;Broderick, J. P.;Jimenez-Conde, J.;Jern, C.;Kissela, B. M.;Kleindorfer, D. O.;Lemmens, R.;Meschia, J. F.;Rosand, J.;Rundek, T.;Sacco, R. L.;Schmidt, R.;Sharma, P.;Slowik, A.;Thijs, V.;Woo, D.;Worrall, B. B.;Kittner, S. J.;Petersson, J.;Golland, P.;Wu, O.;Rost, N. S.;Lindgren, A.
为了检查偏头痛与后循环缺血性卒中（PCiS）和前循环缺血性卒中（ACiS）这两种不同表型之间的潜在遗传关系，我们生成了偏头痛多基因风险评分（PRS），并在 PCiS 和 ACiS 之间进行比较，并分别与非卒中对照受试者进行比较。根据弥散加权 MRI 上的病变位置，将急性缺血性中风病例分为 PCiS 或 ACiS。排除标准是两个血管区域或不确定区域都有病变；幕上 PCiS 与同侧胎儿大脑后动脉；以及心房颤动的病例。我们使用公开的 GWAS 数据生成了三种偏头痛表型（任何偏头痛；无先兆偏头痛；有先兆偏头痛）的偏头痛 PRS，并分别比较了 PCiS 和 ACiS 与非中风对照受试者以及每种中风表型之间的平均 PRS。我们的主要分析包括 464 名具有欧洲遗传血统的 PCiS 和 1079 名 ACiS 患者。与非中风对照受试者 (n=15396) 相比，任何偏头痛的 PRS 均与 PCiS 风险增加 (p=0.01–0.03) 和 ACiS 风险降低 (p=0.010–0.039) 相关。无先兆 PRS 的偏头痛与 PCiS 显着相关 (p=0.008–0.028)，但与 ACiS 无关。直接比较 PCiS 与 ACiS 时，对于任何偏头痛 (p=0.001–0.010) 和无先兆偏头痛 (p=0.032–0.048)，PCiS 与 ACiS 中的偏头痛 PRS 较高。在我们的分析中，先兆 PRS 偏头痛并未显示出差异关联。我们的结果表明，与 ACiS 相比，PCiS 的未明确偏头痛和无先兆偏头痛之间存在更强的遗传重叠。可能的共同机制包括脑血管内皮功能失调。
To examine potential genetic relationships between migraine and the two distinct phenotypes posterior circulation ischemic stroke (PCiS) and anterior circulation ischemic stroke (ACiS), we generated migraine polygenic risk scores (PRSs) and compared these between PCiS and ACiS, and separately vs. non-stroke control subjects. Acute ischemic stroke cases were classified as PCiS or ACiS based on lesion location on diffusion-weighted MRI. Exclusion criteria were lesions in both vascular territories or uncertain territory; supratentorial PCiS with ipsilateral fetal posterior cerebral artery; and cases with atrial fibrillation. We generated migraine PRS for three migraine phenotypes (any migraine; migraine without aura; migraine with aura) using publicly available GWAS data and compared mean PRSs separately for PCiS and ACiS vs. non-stroke control subjects, and between each stroke phenotype. Our primary analyses included 464 PCiS and 1079 ACiS patients with genetic European ancestry. Compared to non-stroke control subjects (n=15396), PRSs of any migraine were associated with increased risk of PCiS (p=0.01–0.03) and decreased risk of ACiS (p=0.010–0.039). Migraine without aura PRSs were significantly associated with PCiS (p=0.008–0.028), but not with ACiS. When comparing PCiS vs. ACiS directly, migraine PRSs were higher in PCiS vs. ACiS for any migraine (p=0.001–0.010) and migraine without aura (p=0.032–0.048). Migraine with aura PRS did not show a differential association in our analyses. Our results suggest a stronger genetic overlap between unspecified migraine and migraine without aura with PCiS compared to ACiS. Possible shared mechanisms include dysregulation of cerebral vessel endothelial function.
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影响因子：
5
作者：
Silvestrini, M;Baruffaldi, R;Provinciali, L
通讯作者：
Provinciali, L
影响因子：
30.8
作者：
Das, Sayantan;Forer, Lukas;Schoenherr, Sebastian;Sidore, Carlo;Locke, Adam E.;Kwong, Alan;Vrieze, Scott I.;Chew, Emily Y.;Levy, Shawn;McGue, Matt;Schlessinger, David;Stambolian, Dwight;Loh, Po-Ru;Iacono, William G.;Swaroop, Anand;Scott, Laura J.;Cucca, Francesco;Kronenberg, Florian;Boehnke, Michael;Abecasis, Goncalo R.;Fuchsberger, Christian
通讯作者：
Fuchsberger, Christian
影响因子：
120.7
作者：
Scher, Ann I.;Gudmundsson, Larus S.;Sigurdsson, Sigurdur;Ghambaryan, Anna;Aspelund, Thor;Eiriksdottir, Gudny;van Buchem, Mark A.;Gudnason, Vilmundur;Launer, Lenore J.
通讯作者：
Launer, Lenore J.
DOI：
10.1016/s1474-4422(21)00031-4
发表时间：
2021-05
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Traylor M;Persyn E;Tomppo L;Klasson S;Abedi V;Bakker MK;Torres N;Li L;Bell S;Rutten-Jacobs L;Tozer DJ;Griessenauer CJ;Zhang Y;Pedersen A;Sharma P;Jimenez-Conde J;Rundek T;Grewal RP;Lindgren A;Meschia JF;Salomaa V;Havulinna A;Kourkoulis C;Crawford K;Marini S;Mitchell BD;Kittner SJ;Rosand J;Dichgans M;Jern C;Strbian D;Fernandez-Cadenas I;Zand R;Ruigrok Y;Rost N;Lemmens R;Rothwell PM;Anderson CD;Wardlaw J;Lewis CM;Markus HS;Helsinki Stroke, Study Dutch Parelsnoer Institute-Cerebrovascular Accident (CVA) Study Group;National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network;UK DNA Lacunar Stroke Study Investigators;International Stroke Genetics Consortium
通讯作者：
International Stroke Genetics Consortium
影响因子：
11
作者：
Rajan, Roopa;Khurana, Dheeraj;Lal, Vivek
通讯作者：
Lal, Vivek