SKK4, a novel activator of stress‐activated protein kinase‐1 (SAPK1/JNK)
SKK4, a novel activator of stress‐activated protein kinase‐1 (SAPK1/JNK)
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SKK4，一种新型应激激活蛋白激酶-1 (SAPK1/JNK) 激活剂
DOI：
10.1016/s0014-5793(97)00990-3
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发表时间：
1997
期刊：
影响因子：
3.5
通讯作者：
Philip R. Cohen
中科院分区：
文献类型：
--
作者：
S. Lawler;A. Cuenda;M. Goedert;Philip R. Cohen
克隆并表达了编码人应激激活蛋白激酶激酶 4 (SKK4) 的 cDNA，SKK4 是一种新型 MAP 激酶激酶家族成员，其 mRNA 在人体组织中广泛表达。 SKK4 在体外激活 SAPK1/JNK，但不激活 SAPK2a/p38、SAPK2b/p38β、SAPK3/ERK6 或 SAPK4。它似乎是 HEP 的哺乳动物同源物，HEP 是果蝇中 SAPK1/JNK 的激活剂。在人上皮KB细胞中，SKK4和SKK1/MKK4（SAPK1/JNK的另一种激活剂）均被应激刺激激活，但只有SKK4被促炎细胞因子激活。 SKK4 的鉴定解释了为什么在许多哺乳动物细胞提取物中检测到的主要 SAPK1/JNK 激活剂可以通过色谱法与 SKK1/MKK4 分离。
A cDNA was cloned and expressed that encodes human stress-activated protein kinase kinase-4 (SKK4), a novel MAP kinase kinase family member whose mRNA is widely expressed in human tissues. SKK4 activated SAPK1/JNK in vitro, but not SAPK2a/p38, SAPK2b/p38β, SAPK3/ERK6 or SAPK4. It appears to be the mammalian homologue of HEP, an activator of SAPK1/JNK in Drosophila. In human epithelial KB cells SKK4 and SKK1/MKK4 (another activator of SAPK1/JNK) were both activated by stressful stimuli, but only SKK4 was activated by proinflammatory cytokines. The identification of SKK4 explains why the major SAPK1/JNK activator detected in many mammalian cell extracts is chromatographically separable from SKK1/MKK4.
DOI：
10.1073/pnas.94.14.7337
发表时间：
1997-07-08
影响因子：
11.1
作者：
Tournier, C;Whitmarsh, AJ;Davis, RJ
通讯作者：
Davis, RJ
影响因子：
10.5
作者：
Sluss, HK;Han, ZQ;Ip, YT
通讯作者：
Ip, YT