The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila.
The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila.
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DOI：
10.1371/journal.pone.0044888
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Edgar BA
中科院分区：
文献类型：
--
作者：
Brown HL;Kaun KR;Edgar BA
Mutations in either of two tumor suppressor genes, TSC1 or TSC2, cause tuberous sclerosis complex (TSC), a syndrome resulting in benign hamartomatous tumors and neurological disorders. Cellular growth defects and neuronal disorganization associated with TSC are believed to be due to upregulated TOR signaling. We overexpressed Rheb, an upstream regulator of TOR, in two different subsets of D. melanogaster central brain neurons in order to upregulate the Tsc-Rheb-TOR pathway. Overexpression of Rheb in either the mushroom bodies or the insulin producing cells resulted in enlarged axon projections and cell bodies, which continued to increase in size with prolonged Rheb expression as the animals aged. Additionally, Rheb overexpression in the mushroom bodies resulted in deficiencies in 3 hr but not immediate appetitive memory. Thus, Rheb overexpression in the central brain neurons of flies causes not only morphological phenotypes, but behavioral and aging phenotypes that may mirror symptoms of TSC.
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影响因子：
1.9
作者：
HEISENBERG, M;BORST, A;BYERS, D
通讯作者：
BYERS, D
影响因子：
9.2
作者：
Brogiolo, W;Stocker, H;Hafen, E
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Hafen, E
影响因子：
5.3
作者：
Fingar, DC;Richardson, CJ;Blenis, J
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Blenis, J
影响因子：
56.9
作者：
Connolly, JB;Roberts, IJH;OKane, CJ
通讯作者：
OKane, CJ
影响因子：
9.2
作者：
Burke, Christopher J.;Waddell, Scott
通讯作者：
Waddell, Scott