Photophysics of glycosylated derivatives of a chlorin, isobacteriochlorin and bacteriochlorin for photodynamic theragnostics: discovery of a two-photon-absorbing photosensitizer.
Photophysics of glycosylated derivatives of a chlorin, isobacteriochlorin and bacteriochlorin for photodynamic theragnostics: discovery of a two-photon-absorbing photosensitizer.
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DOI：
10.1111/php.12179
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发表时间：
2014-03
影响因子：
3.3
通讯作者：
Drain CM
中科院分区：
文献类型：
--
作者：
Aggarwal A;Thompson S;Singh S;Newton B;Moore A;Gao R;Gu X;Mukherjee S;Drain CM
的photophysical性质的二氢卟酚，isobacteriochlorin，和菌绿素建立在一个核心的tetrapentafluorophenylpyrrophin（TPPF 20）和非水解的帕拉巯基糖基化的共轭物，这些发色团。这些化合物的光物理表征是在三种不同的溶剂中进行的，以与细胞和组织中的不同环境相关联。与TPPF 20相比，这些缀合物在可见光谱的红色区域具有更大的吸收和更大的荧光量子产率。激发态寿命为3-11纳秒。由荧光量子产率和激发态寿命估算了激发态失活的辐射和非辐射速率常数。数据表明，菌绿素在730 nm附近具有强吸收带，并有效地进入三重态歧管。异菌绿素具有40-70%的荧光量子产率，这取决于溶剂，因此它可能是一个很好的荧光标记物。异菌绿素还显示出增强的双光子吸收，从而允许使用860 nm的光来激发化合物。虽然25个GM单位的双光子截面不大，但低光和低发色团浓度可诱导细胞凋亡。糖基化化合物在细胞和小鼠头颈部鳞状细胞癌异种移植肿瘤模型中积累。这些化合物对光漂白是稳健的。
The photophysical properties of a chlorin, isobacteriochlorin, and bacteriochlorin built on a core tetrapentafluorophenylporphyrin (TPPF20) and the non-hydrolysable para thioglycosylated conjugates of these chromophores are presented. The photophysical characterization of these compounds was done in three different solvents to correlate to different environments in cells and tissues. Compared to TPPF20 these conjugates have greater absorption in the red region of the visible spectrum and greater fluorescence quantum yields. The excited state lifetimes are from 3-11 nsec. The radiative and non-radiative rate constants for deactivation of the excited state were estimated from the fluorescence quantum yield and excited state lifetime. The data indicates that the bacteriochlorin has strong absorption bands near 730 nm and efficiently enters the triplet manifold. The isobacteriochlorin has a 40-70% fluorescence quantum yield depending on solvent, so it may be a good fluorescent tag. The isobacteriochlorins also display enhanced 2-photon absorption, thereby allowing the use of 860 nm light to excite the compound. While the 2-photon cross section of 25 GM units is not large, low light and low chromophore concentrations can induce apoptosis. The glycosylated compounds accumulate in cells and a head and neck squamous carcinoma xenograft tumor model in mice. These compounds are robust to photobleaching.
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DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
3.6
作者：
Ballut, Severine;Naud-Martin, Delphine;Maillard, Philippe
通讯作者：
Maillard, Philippe
影响因子：
3.2
作者：
Balaz, Milan;Collins, Hazel A.;Anderson, Harry L.
通讯作者：
Anderson, Harry L.
影响因子：
3.3
作者：
Allison, Ron R.;Downie, Gordon H.;Sibata, Claudio H.
通讯作者：
Sibata, Claudio H.
影响因子：
15
作者：
Drobizhev, Mikhail;Stepanenko, Yuriy;Anderson, Harry L.
通讯作者：
Anderson, Harry L.