Implicit sensorimotor adaptation is preserved in Parkinson's disease.
Implicit sensorimotor adaptation is preserved in Parkinson's disease.
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帕金森病患者的内隐感觉运动适应能力得以保留。
DOI：
10.1093/braincomms/fcac303
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
我们制定成功的目标导向行动的能力涉及多个学习过程。在这些过程中，内隐运动适应确保感觉运动系统保持微调，以响应身体和环境的变化。帕金森病是否影响内隐运动适应仍然是一个有争议的研究领域：虽然多份报告显示这一人群的表现受损，但许多其他人表现完好。虽然有一系列的研究方法的差异，一个关键问题是，在许多研究的表现可能反映了一个组合的内隐适应和战略重新瞄准。在这里，我们重新审视了这一争议使用的视觉任务，旨在隔离内隐适应。在两个实验中，我们发现帕金森病患者和对照组参与者对大范围视觉干扰的适应性相似。此外，在对先前发表和未发表的工作进行的荟萃分析中，我们发现，在涉及200多名参与者的16项实验中，帕金森病和对照组的平均效应大小并不显著。总之，这些分析表明，内隐适应是保留在帕金森氏病，提供了一个新的视角基底神经节在感觉运动学习的作用。Tsay等人研究了帕金森病对感觉运动适应的影响。两项实验和一项荟萃分析的结果提供了令人信服的证据，表明帕金森病患者的内隐适应得以保留，并表明基底神经节对适应任务的贡献可能与其他学习过程有关。
Our ability to enact successful goal-directed actions involves multiple learning processes. Among these processes, implicit motor adaptation ensures that the sensorimotor system remains finely tuned in response to changes in the body and environment. Whether Parkinson’s disease impacts implicit motor adaptation remains a contentious area of research: whereas multiple reports show impaired performance in this population, many others show intact performance. While there is a range of methodological differences across studies, one critical issue is that performance in many of the studies may reflect a combination of implicit adaptation and strategic re-aiming. Here, we revisited this controversy using a visuomotor task designed to isolate implicit adaptation. In two experiments, we found that adaptation in response to a wide range of visual perturbations was similar in Parkinson’s disease and matched control participants. Moreover, in a meta-analysis of previously published and unpublished work, we found that the mean effect size contrasting Parkinson’s disease and controls across 16 experiments involving over 200 participants was not significant. Together, these analyses indicate that implicit adaptation is preserved in Parkinson’s disease, offering a fresh perspective on the role of the basal ganglia in sensorimotor learning. Tsay et al. examined the effect of Parkinson’s disease on sensorimotor adaptation. The results from two experiments and a meta-analysis provide compelling evidence that implicit adaptation is preserved in participants with Parkinson’s disease, and suggest that the contribution of the basal ganglia on adaptation tasks may be related to other learning processes.
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DOI：
10.3233/jad-170203
发表时间：
2017
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Borland E;Nägga K;Nilsson PM;Minthon L;Nilsson ED;Palmqvist S
通讯作者：
Palmqvist S
影响因子：
64.8
作者：
Herzfeld DJ;Kojima Y;Soetedjo R;Shadmehr R
通讯作者：
Shadmehr R
影响因子：
9.9
作者：
Dalrymple-Alford, J. C.;MacAskill, M. R.;Anderson, T. J.
通讯作者：
Anderson, T. J.
影响因子：
2.5
作者：
Dawidowicz, Gefen;Shaine, Yuval;Mawase, Firas
通讯作者：
Mawase, Firas
影响因子：
29.9
作者：
Albert, Scott T.;Jang, Jihoon;Shadmehr, Reza
通讯作者：
Shadmehr, Reza