Gender-specific correlates of nonmedical use of prescription medications in a diverse primary care sample.
Gender-specific correlates of nonmedical use of prescription medications in a diverse primary care sample.
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DOI：
10.1016/j.drugalcdep.2022.109399
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发表时间：
2022-05-01
影响因子：
4.2
通讯作者：
Svikis, Dace
中科院分区：
文献类型：
--
作者：
Crouch, Taylor B.;Martin, Caitlin E.;Polak, Kathryn;Smith, Wally;Dillon, Pamela;Ondersma, Steve;Svikis, Dace
非医疗使用处方药（NUPM）是一个日益严重的问题，但很少有人知道其性别特异性机制，尽管NIDA的呼吁性别分层研究十多年前。我们探讨了NUPM在不同样本的初级保健患者的性别差异。N = 4，458名参与者参加了城市初级保健诊所的匿名健康调查。主要结局是上个月的NUPM。所有分析均按性别分层。NUPM和人口统计学，医疗，心理和物质使用相关变量之间的双变量关系进行了分析。按性别估计逐步多元逻辑回归模型（LRM）。报告NUPM的男性（9.5%）多于女性（7.4%）。男性最终的LRM包括年龄（OR=0.98）、种族（OR=0.49）、慢性疼痛诊断（OR=1.73）、肝炎（OR=1.78）、抑郁诊断（OR= 1.77）、酒精滥用筛查阳性（OR=1.58）和情绪障碍（OR=1.04）。在女性中，模型包括情绪障碍（OR=1.04），非法药物使用（OR=2.22），药物问题家族史（OR=1.41）和心脏病诊断（OR=0.48）。影响大小从小到中等不等。在初级保健患者的样本中，性别分层分析表明NUPM的性别差异。人口统计学因素在男性中更相关，年轻的白色男性风险更高。慢性疼痛和抑郁是男性更显著的危险因素。最近的非法药物使用和药物问题的家族史在妇女中是唯一相关的，而最近的痛苦是男性和女性的一个强相关。更好地了解NUPM的性别相关性可以为针对性别的预防和治疗工作提供信息。
Nonmedical use of prescription medications (NUPM) is a growing problem but little is known about its gender-specific mechanisms despite NIDA’s call for gender-stratified research over a decade ago. We explored gender differences in NUPM in a diverse sample of primary care patients. N = 4,458 participants participated in an anonymous health survey in urban primary care clinics. The primary outcome was past month NUPM. All analyses were stratified by gender. Bivariate relationships among NUPM and demographic, medical, psychological, and substance use-related variables were analyzed. Stepwise multivariate logistic regression models (LRMs) were estimated by gender. More men (9.5%) reported NUPM than women (7.4%). The final LRM among men included age (OR=0.98), race (OR=0.49), chronic pain diagnosis (OR=1.73), hepatitis (OR=1.78), depression diagnosis (OR=1.77), positive alcohol misuse screen (OR=1.58), and mood disturbance (OR=1.04). Among women, the model included mood disturbance (OR=1.04), illicit drug use (OR=2.22), family history of drug problems (OR=1.41), and heart disease diagnosis (OR=0.48). Effect sizes ranged from small to moderate. Among a sample of primary care patients, gender-stratified analyses indicated differential presentation of NUPM by gender. Demographic factors were more relevant correlates among men, with younger, White men at higher risk. Chronic pain and depression were more notable risk factors for men. Recent illicit drug use and family history of drug problems were uniquely associated among women, while recent distress was a strong correlate among both men and women. A better understanding of gender-specific correlates of NUPM can inform gender-tailored prevention and treatment efforts.
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影响因子：
3.1
作者：
Martin CE;Ksinan AJ;Moeller FG;Dick D;Spit for Science Working Group
通讯作者：
Spit for Science Working Group
影响因子：
5.5
作者：
Manubay J;Davidson J;Vosburg S;Jones J;Comer S;Sullivan M
通讯作者：
Sullivan M
影响因子：
3.9
作者：
McHugh, R. Kathryn;DeVito, Elise E.;Weiss, Roger D.
通讯作者：
Weiss, Roger D.
影响因子：
1.8
作者：
Kelpin, Sydney S.;Rusteikas, Scott G.;Svikis, Dace S.
通讯作者：
Svikis, Dace S.
DOI：
10.1016/j.japh.2019.03.009
发表时间：
2019-07-01
影响因子：
2.1
作者：
Kim, Uriel;Kim, Noel
通讯作者：
Kim, Noel