Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial.
Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial.
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DOI：
10.1186/1472-6882-14-237
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发表时间：
2014-07-11
影响因子：
--
通讯作者：
Chae SW
中科院分区：
文献类型：
--
作者：
Oh MR;Park SH;Kim SY;Back HI;Kim MG;Jeon JY;Ha KC;Na WT;Cha YS;Park BH;Park TS;Chae SW
红参是通过蒸生人参制成的，这一过程被认为可以提高药理功效。通过发酵对红参进行进一步的生物转化可以增加其肠道吸收和生物活性，而生物转化可以降低红参代谢产物的毒性。本研究旨在探讨每日补充发酵红参(FRG)对空腹血糖受损或2型糖尿病患者血糖状态的影响。这项研究是一项为期四周的随机、双盲、安慰剂对照试验。42名空腹血糖受损或2型糖尿病的受试者被随机分配到两组，分别服用安慰剂或发酵红参(FRG)，每天三次，持续四周。在干预前后对饮食耐量试验中的空腹和餐后血糖进行评估。与安慰剂组相比，补充FRG导致餐后血糖水平显著降低，并导致餐后胰岛素水平上升。FRG组的血糖曲线下面积(AUC)持续显著改善。然而，空腹血糖、胰岛素和血脂谱与安慰剂组没有不同。每日补充FRG可降低空腹血糖受损或2型糖尿病受试者的餐后血糖水平。ClinicalTrials.gov：NCT01826409
Red ginseng is prepared by steaming raw ginseng, a process believed to increase the pharmacological efficacy. Further bioconversion of red ginseng through fermentation is known to increase its intestinal absorption and bioactivity, and bioconversion diminishes the toxicity of red ginseng’s metabolite. This study was conducted to investigate the effects of daily supplementation with fermented red ginseng (FRG) on glycemic status in subjects with impaired fasting glucose or type 2 diabetes. This study was a four-week long, randomized, double-blind, placebo-controlled trial. Forty-two subjects with impaired fasting glucose or type 2 diabetes were randomly allocated to two groups assigned to consume either the placebo or fermented red ginseng (FRG) three times per day for four weeks. Fasting and postprandial glucose profiles during meal tolerance tests were assessed before and after the intervention. FRG supplementation led to a significant reduction in postprandial glucose levels and led to an increase in postprandial insulin levels compared to the placebo group. There was a consistently significant improvement in the glucose area under the curve (AUC) in the FRG group. However, fasting glucose, insulin, and lipid profiles were not different from the placebo group. Daily supplementation with FRG lowered postprandial glucose levels in subjects with impaired fasting glucose or type 2 diabetes. ClinicalTrials.gov: NCT01826409
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影响因子：
2
作者：
Bae, EA;Park, SY;Kim, DH
通讯作者：
Kim, DH
影响因子：
3
作者：
Kim, Bong-Gwan;Shin, Kwang-Soon;Suh, Hyung Joo
通讯作者：
Suh, Hyung Joo
DOI：
10.1080/07315724.2006.10719519
发表时间：
2006-04-01
影响因子：
3.5
作者：
Sievenpiper, JL;Sung, MK;Vuksan, V
通讯作者：
Vuksan, V
影响因子：
3.9
作者：
Ha, Kyoung-Soo;Jo, Sung-Hoon;Kwon, Young-In
通讯作者：
Kwon, Young-In
影响因子：
7.2
作者：
Li, Houkai;Zhou, Mingmei;Jia, Wei
通讯作者：
Jia, Wei